Results 71 to 80 of about 25,303 (208)

An “acquired” hemoglobin J variant in a sickle cell disease patient

Therapeutics and Clinical Risk Management, 2008
Nawwar Swedan1, Kathleen Nicol2, Phylis Moder2, Samir Kahwash21Fellow in Transfusion Medicine, Ohio State University, Columbus, Ohio; 2Department of Laboratory Medicine, Nationwide Children’s Hospital, Columbus, OhioAbstract: We report the case
Nawwar Swedan, Kathleen Nicol, Phylis Moder, Samir Kahwash   +3 more
doaj  

Voxelotor does not inhibit sickle hemoglobin fiber formation upon complete deoxygenation. [PDF]

Biophys J, 2023
Worth EH, Fugate MK, Ferrone FA.
europepmc   +1 more source

Fetal hemoglobin in sickle cell anemia

Blood, 2020
AbstractFetal hemoglobin (HbF) can blunt the pathophysiology, temper the clinical course, and offer prospects for curative therapy of sickle cell disease. This review focuses on (1) HbF quantitative trait loci and the geography of β-globin gene haplotypes, especially those found in the Middle East; (2) how HbF might differentially impact the ...
openaire   +3 more sources

Integrating primary care for depression management during transition in sickle cell disease: A pre–post feasibility study

British Journal of Haematology, EarlyView.
Robert M. Cronin, Nives Quaye, Kristina Landes, Roberta Azbell, Sherraine Della‐Moretta, Regina D. Crawford, Chyongchiou J. Lin, Susan Creary, Patrick M. Schnell   +8 more
wiley   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

ELEVATED MEAN CELL VOLUME IN SICKLE CELL ANAEMIA: ONE STORY, TOO MANY? [PDF]

Sanamed
Introduction: Sickle cell disease is a hereditary blood disorder characterized by defective hemoglobin. Red cell indices are proposed as potential tools for diagnosing and managing sickle cell disorders.
Jeremiah Zaccheaus, Alee Magnus
doaj   +1 more source

Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling. [PDF]

Nat Commun, 2023
De Souza DC, Hebert N, Esrick EB, Ciuculescu MF, Archer NM, Armant M, Audureau É, Brendel C, Di Caprio G, Galactéros F, Liu D, McCabe A, Morris E, Schonbrun E, Williams D, Wood DK, Williams DA, Bartolucci P, Higgins JM.   +18 more
europepmc   +1 more source

Outcomes of dengue infection in adults with underlying haematological diseases in Brazil during 2024 and 2025

British Journal of Haematology, EarlyView.
K. Tozatto‐Maio, V. Weihermann, C. W. Erthal, M. W. Araújo, C. R. Gomes, K. Caciola, L. Otuyama, J. Gasparini, H. R. Higashino, S. F. Costa, A. N. Duarte‐Neto, F. S. Seguro, P. R. Villaça, E. D. R. P. Velloso, S. F. M. Gualandro, Y. Nukui, V. Rocha   +16 more
wiley   +1 more source

Seventh Åland Island Meeting on von Willebrand Disease

Haemophilia, EarlyView.
ABSTRACT Introduction The seventh Åland Island Meeting on von Willebrand Disease (VWD) was held on the Åland archipelago in Finland, from 26 to 28 September 2024. Aim The meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD.
Riitta Lassila, Ruben Bierings, Nathan T. Connell, Fernando F. Corrales‐Medina, Augusto B. Federici, Veronica H. Flood, Floor Heubel‐Moenen, Jill M. Johnsen, Geoffrey Kuppens, Davide Matino, Carolyn Millar, Ingmar Schoen, Anish Sharda, Robert F. Sidonio Jr, Alok Srivastava, Timea Szanto, Angela C. Weyand, Erik Berntorp   +17 more
wiley   +1 more source

Determining of the Hydroxyurea Effluence on TCD Parameters of Sickle Cell Patients

مجله دانشکده پزشکی اصفهان, 2009
Background: Sickle cell disease is the most common hemoglobinopathies that affect a specific intracellular protein named as hemoglobin. This disease has several clinical manifestations including, CNS involvement.
Nasser Sharafadinzadeh, Nastaran Majdinasb, Khodamorad Zandian, Keiwan Taherpoor, Armaghan Moravej Aleali, Mohamad Pipelzadeh   +5 more
doaj