Results 51 to 60 of about 204,284 (265)

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Polymorphism In The Hmox1 Gene Is Associated With High Levels Of Fetal Hemoglobin In Brazilian Patients With Sickle Cell Anemia.

, 2015
The aim of this study was to investigate the association between three polymorphisms involved in the oxidative stress pathway and fetal hemoglobin (Hb F) levels in patients with sickle cell anemia in a Brazilian population. One hundred and seven patients
Oliveira, Mariana B, Silva, Márcio J, Araujo, Aderson S, Hatzlhofer, Betânia L D, Gil, Gislene P, Ananina, Galina, Santos, Magnun N N, Melo, Mônica B, Costa, Fernando F, Bezerra, Marcos A C   +9 more
core   +2 more sources

Ceftriaxone‐associated immune haemolytic anaemia: A patient‐level systematic review

British Journal of Clinical Pharmacology, EarlyView.
Abstract Ceftriaxone can cause acute haemolysis. Its clinical presentation, risk factors, and outcomes remain incompletely characterized. We conducted a systematic review of published cases with patient‐level data, following international guidelines and with registration in PROSPERO (CRD420261338709). Reports were identified through three bibliographic
Sonja Miotti, Giada Wyttenbach, Mario G. Bianchetti, Camilla Lavagno, Pietro Camozzi, Gregorio P. Milani, Renato Gualtieri, Sebastiano A. G. Lava, Pietro B. Faré, Simone Janett   +9 more
wiley   +1 more source

Clinico-hematological parameters of sickle hemoglobin hemoglobinopathies and its correlation with ethnicity: A study from Northern Districts of West Bengal

Biomedical and Biotechnology Research Journal, 2020
Background: Inherited disorders of blood include thalassemias and hemoglobinopathies which are one of the major public problems in India. In sickle hemoglobin (HbS) hemoglobinopathies, production of abnormal sickle-shaped red cells results in variable ...
Bidyut Krishna Goswami, Rajashri Chakrabarty, Subrata Bhattacharjee, Ankita Dhanuka, Sarama Banerjee Goswami, Sudipta Chakrabarti   +5 more
doaj   +1 more source

Association of haptoglobin levels with age, parasite density, and haptoglobin genotype in a malaria-endemic area of Gabon. [PDF]

, 2006
Item does not contain fulltextHaptoglobin (Hp) levels were investigated in relation to host genotype in a malaria-endemic area in Gabon. A cross-sectional study of 1-12-year-old children was conducted in the rainy season, a period of high malaria ...
Michon, P., Deloron, P, Justice, A, Luty, A.J.F., Migot Nabias, Florence, Migot-Nabias, F, Imrie, H, Deloron, P., Justice, A., Deloron, Philippe, Fowkes, FJI, Michon, P, Luty, JF, Fowkes, F.J., Day, K.P., Imrie, H., Migot-Nabias, F., Day, KP, Fowkes, F.J.I   +18 more
core   +1 more source

Small scale purification and biophysical characterization of haptoglobin derived from human Cohn fraction IV

Biotechnology Progress, EarlyView.
Abstract Haptoglobin (Hp) is a polymorphic acute phase α‐2 glycoprotein found in plasma that plays a critical role in binding, neutralizing, and removing cell‐free hemoglobin (Hb) from the circulation. Under clinical conditions characterized by high levels of hemolysis, such as in patients with sickle cell disease (SCD), large quantities of cell‐free ...
Shuwei Lu, Mohd Asim Khan, Pedro Cabrales, David C. Irwin, Paul W. Buehler, Andre F. Palmer   +5 more
wiley   +1 more source

Prevalence of hemolytic anemia and hemoglobinopathies among the pregnant women attending a tertiary hospital in central India

Thalassemia Reports, 2015
Anemia in pregnancy is one of the causes of maternal morbidity and, maternal and fetal mortality in India. Hemoglobin transports oxygen to different parts of the body. Any defect in hemoglobin structure leads to its adverse functions.
Ranbir S. Balgir
doaj   +1 more source

Microalbuminuria as Predictor of Early Glomerular Injury in Children and Adolescents with Sickle Cell Anaemia at Muhimbili National Hospital Dar es Salaam, Tanzania 2012 [PDF]

, 2012
Microalbuminuria (MA) is the earliest marker of various diseases affecting the renal system. Its relevance in children and adolescents with sickle cell anaemia (SCA), who are known to be prone to renal complications, has not been fully explored in our ...
Christopher, Richard, Christopher, R.
core  

Haplotype association between haptoglobin (Hp2) and Hp promoter SNP (A-61C) may explain previous controversy of haptoglobin and malaria protection. [PDF]

, 2007
BACKGROUND: Malaria is one of the strongest recent selective pressures on the human genome, as evidenced by the high levels of varying haemoglobinopathies in human populations-despite the increased risk of mortality in the homozygous states.
Andrew M Prentice, Chidi V Nweneka, Kirk A Rockett, Nweneka, Chidi V, Ghattas Hala, Kwiatkowski, DP, Fulford, AJ, Sharon E. Cox, Kwiatkowski, Dominic, Dominic P Kwiatkowski, Kwiatkowski Dominic P., Kirk A. Rockett, Atkinson, Sarah H., Sharon E Cox, Atkinson, SH, Nweneka, Chidi V., Rockett, KA, Dominic P. Kwiatkowski, Ghattas, H, Anthony J.C. Fulford, Fulford, Anthony J. C., Atkinson Sarah H., Sarah H. Atkinson, Kwiatkowski, Dominic P., Cox, Sharon E, Prentice, Andrew M., Doherty, Conor, Nweneka, CV, Conor Doherty, Cox, Sharon E., Doherty, C, Rockett, Kirk A., Prentice, AM, Nweneka Chidi V., Anthony J C Fulford, Prentice, Andrew M, Ghattas, Hala, Chidi V. Nweneka, Rockett, Kirk A, Sarah H Atkinson, Fulford, Anthony JC, Cox Sharon E., Fulford, Anthony J.C., Cox, SE, Rockett Kirk A., Fulford Anthony J.C., Atkinson, Sarah H, Hala Ghattas, Andrew M. Prentice, Atkinson, Sarah, Prentice Andrew M., Doherty Conor, Kwiatkowski, Dominic P   +52 more
core   +1 more source

Model‐Informed Evaluation of Hydroxyurea Exposure During Lactation

Clinical Pharmacology &Therapeutics, EarlyView.
Hydroxyurea is a cornerstone therapy for sickle cell anemia; however, evidence guiding its use during lactation remains limited. This study aimed to develop a population pharmacokinetic (PK) model to characterize hydroxyurea disposition in maternal plasma and breast milk, and to quantify infant exposure under clinically relevant breastfeeding scenarios.
Anhar Hosawi, Kei Irie, Min Dong, Julie Ware, Russell Ware, Tomoyuki Mizuno   +5 more
wiley   +1 more source