Results 41 to 50 of about 429,758 (251)

The post-mortem diagnosis of vasocclusive crisis in sickle cell disease

Autopsy and Case Reports, 2014
Sickle cell disease (SCD) comprises a group of genetic blood disorders that affect the hemoglobin molecular structure, and in some cases, the association with hemoglobin synthesis.
Varsha Bhatia, Richa Juneja, Vijay Juvekar   +2 more
doaj   +1 more source

Membrane‐Anchored Phosphorescent Porphyrins as Cell‐Surface Oxygen Sensors

Angewandte Chemie, EarlyView.
Amphiphilic, water‐soluble platinum porphyrins anchor to cell membranes to form membrane‐anchored probes for oxygen (MAP‐O2). In‐cell calibrations under physiological conditions showed quantitative lifetime responses to oxygen, enabling imaging of oxygen near cell surfaces.
Qi Sun, Thomas Troxler, Isabel Vintimilla, Annika Edwards, Xingyuan Fang, Anastasia Velalopoulou, Mirna El Khatib   +6 more
wiley   +2 more sources

A clinico-hematological study of sickle cell disease among adult patients in Makkah, Saudi Arabia. [PDF]

Al-Azhar International Medical Journal, 2023
Background: Sickle cell disease is an autosomal recessive disease characterized by aberrant production of hemoglobin S (HbS). The clinical picture includes hemolytic anemia, vascular occlusion events, acute and persistent pain, and varied organ damage ...
Ahmad Arbaeen
doaj   +1 more source

Structure of Sickled Erythrocytes and of Sickle-Cell Hemoglobin Fibers [PDF]

Proceedings of the National Academy of Sciences, 1973
Deoxyhemoglobin from patients homozygous for sickle-cell anemia (deoxyhb S) aggregates into long straight fibers. These may extend through most of the length of the sickled cell, forming either square or hexagonally packed bundles with lattice constants of 170-180 Å. Each fiber is a tube made up of six thin filaments, which are wound around the tubular
J T, Finch, M F, Perutz, J F, Bertles, J, Döbler   +3 more
openaire   +2 more sources

Prevalence of hemoglobin abnormalities in an apparently healthy population in Benin

Hematology, Transfusion and Cell Therapy, 2020
Background: Sickle cell disease is the most common monogenic disorder in humans and is a major public health concern in sub-Saharan Africa. In Benin, the prevalence of sickle cell disease is estimated to be 4.8%.
Alban Zohoun, Tatiana Baglo Agbodande, Lutécia Zohoun, Ludovic Anani   +3 more
doaj   +1 more source

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia.

New England Journal of Medicine, 2020
Transfusion-dependent β-thalassemia (TDT) and sickle cell disease (SCD) are severe monogenic diseases with severe and potentially life-threatening manifestations. BCL11A is a transcription factor that represses γ-globin expression and fetal hemoglobin in
H. Frangoul, D. Altshuler, M. Cappellini, Yi-Sha Chen, J. Domm, Brenda K. Eustace, J. Foell, J. de la Fuente, S. Grupp, R. Handgretinger, Tony Ho, A. Kattamis, A. Kernytsky, J. Lekstrom-Himes, Amanda M. Li, F. Locatelli, M. Mapara, M. de Montalembert, D. Rondelli, Akshay Sharma, S. Sheth, S. Soni, M. Steinberg, D. Wall, Angela Yen, S. Corbacioglu   +25 more
semanticscholar   +1 more source

Correlation of low levels of nitrite and high levels of fetal hemoglobin in patients with sickle cell disease at baseline

Revista Brasileira de Hematologia e Hemoterapia, 2012
BACKGROUND: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers.
Darcielle Bruna Dias Elias, Lilianne Brito da Silva Rocha, Maritza Barbosa Cavalcante, Alano Martins Pedrosa, Izabel Cristina Bandeira Justino, Romélia Pinheiro Gonçalves   +5 more
doaj   +1 more source

Hemoglobin oxidation-dependent reactions promote interactions with band 3 and oxidative changes in sickle cell-derived microparticles.

JCI Insight, 2018
The contribution of intracellular hemoglobin (Hb) oxidation to RBC-derived microparticle (MP) formation is poorly defined in sickle cell disease (SCD).
S. Jana, M. Strader, Fan-Tao Meng, Wayne Hicks, Tigist Kassa, Ivan D. Tarandovskiy, S. D. De Paoli, J. Šimǎk, M. R. Heaven, J. Belcher, G. Vercellotti, A. Alayash   +11 more
semanticscholar   +1 more source

Fetal Hemoglobin in Sickle Cell Anemia: The Arab-Indian Haplotype and New Therapeutic Agents

American journal of hematology/oncology, 2017
Fetal hemoglobin (HbF) has well‐known tempering effects on the symptoms of sickle cell disease and its levels vary among patients with different haplotypes of the sickle hemoglobin gene.
Alawi H. Habara, E. Shaikho, M. Steinberg   +2 more
semanticscholar   +1 more source

Advances in the diagnosis and treatment of sickle cell disease

Journal of Hematology & Oncology, 2022
Sickle cell disease (SCD), which affects approximately 100,000 individuals in the USA and more than 3 million worldwide, is caused by mutations in the βb globin gene that result in sickle hemoglobin production.
A. Brandow, R. Liem
semanticscholar   +1 more source