Results 211 to 220 of about 46,454 (250)
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Oxygen binding to sickle cell hemoglobin
Journal of Molecular Biology, 1979Abstract The extent of oxygen binding and light scattering of concentrated solutions of hemoglobin S have been determined as a function of oxygen partial pressure using a thin film optical cell. Nearly reversible oxygen binding is observed as witnessed by the small hysteresis found between slow deoxygenation and reoxygenation runs.
S J, Gill +4 more
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Alternative diaspirins for modification of hemoglobin and sickle hemoglobin
Archives of Biochemistry and Biophysics, 1984Studies of modification of hemoglobin and of sickle hemoglobin by alternative aspirins have been extended to a series of new bis esters with a variety of substituted bridging diacids and to a group of mono esters with polar acyl groups. Rates of hydrolysis of these alternative aspirins have also been examined, and they reveal that a careful balance ...
E J, Delaney +3 more
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Sickle Cell Anemia and Fetal Hemoglobin
The American Journal of the Medical Sciences, 1994Fetal hemoglobin, the predominant hemoglobin of the fetus, is good for sickle cell anemia. This hemoglobin inhibits the polymerization of sickle hemoglobin. Clinical studies have shown that at any level of fetal hemoglobin, the more that is present, the better off is the patient.
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The oxygen affinity of sickle hemoglobin
Respiratory Physiology & Neurobiology, 2008The right-shifted oxyhemoglobin dissociation curve of sickle cell disease (SCD) has been thought to result in abnormally low arterial oxygen saturation (S(o)(2)), even when oxygen partial pressure (P(o)(2)) is normal. However, without polymer formation (minimal under normoxic conditions), HbS oxygen affinity is normal.
Amgad, Abdu +2 more
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Polymorphism of sickle cell hemoglobin fibers
Journal of Molecular Biology, 1976Polymorphism in the assembly of sickle cell hemoglobin has been studied by electron microscopy of negatively stained fibers of hemoglobin S obtained by lysis of sickled cells with phosphotungstic acid. The structures observed include linear strands of hemoglobin molecules (designated monofilaments), helical fibers composed of multiple monofilaments and
R, Josephs, H S, Jarosch, S J, Edelstein
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Structural analysis of polymers of sickle cell hemoglobin. I. Sickle hemoglobin fibers.
Journal of molecular biology, 1988The structure of fibers of deoxyhemoglobin S has been under investigation for several years and a number of different models have been proposed for the arrangement of molecules within the particles. We have used reconstruction and modeling techniques in our analysis of these structures.
B, Carragher +4 more
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Filter failures with sickling hemoglobin
Transfusion, 2009Eapen K, Jacob +4 more
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Neonatal Screening for Sickle Hemoglobin
American Journal of Clinical Pathology, 1979G, Serjeant, B, Serjeant
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Base editing of haematopoietic stem cells rescues sickle cell disease in mice
Nature, 2021Gregory A Newby +2 more
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