Results 31 to 40 of about 1,352,611 (298)

Design, synthesis, conformational analysis, and biological activity of Cα1-to-Cα6 1,4- and 4,1-disubstituted 1H-[1,2,3]triazol-1-yl-bridged oxytocin analogues

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2023
Oxytocin (OT) is a neurohypophyseal peptide hormone containing a disulphide-bridged pseudocyclic conformation. The biomedical use of OT peptides is limited amongst others by disadvantageous pharmacokinetic parameters.
Francesca Nuti   +13 more
doaj   +1 more source

An extreme-phenotype genome‐wide association study identifies candidate cannabinoid pathway genes in Cannabis

open access: yesScientific Reports, 2020
Cannabis produces a class of isoprenylated resorcinyl polyketides known as cannabinoids, a subset of which are medically important and exclusive to this plant. The cannabinoid alkyl group is a critical structural feature that governs therapeutic activity.
Matthew T. Welling   +5 more
doaj   +1 more source

Monte Carlo simulations reveal the straightening up of an end-grafted flexible chain with a rigid side chain

open access: yes, 2007
We have studied the conformational properties of a flexible end-grafted chain (length $N$) with a rigid side chain (length $S$) by means of Monte Carlo simulations.
A. Halperin   +4 more
core   +1 more source

Effect of Block Length and Side Chain Length Ratios on Determining a Multicompartment Micelle Structure

open access: yesThe Journal of Physical Chemistry B, 2019
Previous work has identified the importance of the lipophilic-fluorophilic block length ratio Rl in predicting the morphology of linear lipophilic-hydrophilic-fluorophilic (hereafter referred to as BAC) micelle systems. Here, a generalized form R of this structural parameter is developed that makes no assumption of BAC triblock co-polymer linearity ...
Connor P. Callaway   +4 more
openaire   +3 more sources

Side-chain influence on the mass density and refractive index of polyfluorenes and star-shaped oligofluorene truxenes [PDF]

open access: yes, 2015
The density of organic semiconductor films is an important quantity because it is related to intermolecular spacing which in turn determines the electronic and photophysical properties.
Allard, Sybille   +12 more
core   +1 more source

Size Matters: Side Chain Length Affects SH2 Substrate Binding

open access: yesChemistry & Biology, 2010
The incorporation of lysine analogs in Src Homology 2 (SH2) domain variants by Virdee et al. (2010) reveals the length-dependent contribution of a single amino acid side chain in recognition of phosphotyrosine-containing substrate peptides and a change in specificity with shorter side chains.
openaire   +2 more sources

Investigating nano-structuring within imidazolium ionic liquids: A thermodynamic study using photochromic molecular probes [PDF]

open access: yes, 2009
Following previous studies involving the thermal relaxation of spirocyclic compounds we extended our studies to investigate the formation of nano-structured domains in ionic liquids (ILs).
Byrne, Robert   +3 more
core   +1 more source

Spectrophotometric analysis of ternary uranyl systems to replace tri-N-butyl phosphate (TBP) in used fuel reprocessing [PDF]

open access: yes, 2020
In this report, the interaction of monoamide/diamide and monoamide/diglycolamide mixtures with UO2+2 are investigated in pH = 1 methanolic nitric acid media.
Babra, Jasraj S.   +5 more
core   +2 more sources

Unavoidable induced subgraphs in large graphs with no homogeneous sets [PDF]

open access: yes, 2015
A homogeneous set of an $n$-vertex graph is a set $X$ of vertices ($2\le |X|\le n-1$) such that every vertex not in $X$ is either complete or anticomplete to $X$. A graph is called prime if it has no homogeneous set.
Diestel   +12 more
core   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

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