Results 31 to 40 of about 372,822 (251)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Exploring the impact of the side-chain length on peptide/RNA binding events

Physical Chemistry Chemical Physics, 2017
The impact of the amino-acid side-chain length on peptide–RNA binding events has been investigated using HIV-1 Tat derived peptides as ligands and the HIV-1 TAR RNA element as an RNA model.
Lola Sbicca, Alejandro López González, Alexandra Gresika, Audrey Di Giorgio, Jordi Teixido Closa, Roger Estrada Tejedor, Marie-Line Andréola, Stéphane Azoulay, Nadia Patino   +8 more
openaire   +2 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Effects of side-chain structure and spacing on the assemblies of perfluorosulfonic acid ionomers and local oxygen transport in PEM fuel cells

Nano Research
Molecular dynamics simulations were conducted to investigate the effects of side-chain structure and spacing on the self-assembly behaviors of perfluorosulfonic acid (PFSA) ionomers in both bulk proton exchange membrane (PEM) and nano-thin films within ...
Zhenying Zheng, Meihua Tang, Shengli Chen   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Nonionic surfactants and their effects on asymmetric reduction of 2-octanone with Saccharomyces cerevisiae

AMB Express, 2018
In an aqueous buffer system, serious reverse and side reactions were found in the asymmetric reduction of 2-octanone with Saccharomyces cerevisiae. However, some nonionic surfactants added to the aqueous buffer system improved the bioreduction process by
Yunquan Zheng, Liangbin Li, Xianai Shi, Zhijian Huang, Feng Li, Jianmin Yang, Yanghao Guo   +6 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

An Ionic Transfer Investigation of Tri-Iodine of Solvent-Free Oligomeric Electrolytes in Dye-Sensitized Solar Cells

International Journal of Electrochemical Science, 2011
A series of novel solvent-free oligomeric electrolytes based on poly (ethyl glycol) methyl ether methacrylate for dye-sensitized solar cells (DSSCs) are currently under development. The aim of this study was to investigate the effects of tri-iodine (I3-)
Fu-Ming Wang, Chia-Hsien Chu, Chia-Hua Lee, Jia-Yin Wu, Kun-Mu Lee, Yung-Liang Tung, Chang-Ho Liou, Yung-Yun Wang, Chi-Chao Wan   +8 more
doaj   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source