Results 71 to 80 of about 372,822 (251)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Transport in perfluorosulfonic acid (PFSA) membranes: effects of pretreatment, side-chain length, and alkali metal cation

Frontiers in Membrane Science and Technology
This work investigates the effects of pretreatment, side-chain length, cation type, and the interplay between them on transport properties in the commercial PFSA membranes, Nafion 115 and Aquivion E98-09S. Solutions of 1M LiCl, NaCl, and KCl were used to
Sebastian Castro, Sebastian Castro, Dennis Ssekimpi, Youneng Tang, Daniel Hallinan, Daniel Hallinan   +5 more
doaj   +1 more source

Synthesis and antifungal properties of papulacandin derivatives

Beilstein Journal of Organic Chemistry, 2012
Derivatives of an antifungal agent that targets the β-(1,3)-D-glucan synthase, papulacandin D, were synthesized and tested for activity. The papulacandin D structure contains a challenging benzannulated spiroketal unit, which is introduced in a palladium-
Marjolein van der Kaaden, Eefjan Breukink, Roland J. Pieters   +2 more
doaj   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Influence of Side Chain Length on the Self-Assembly

, 2007
We report on the phase behavior of poly(9,9-dihexylfluorene) (PF6), poly(9,9-diheptylfluorene) (PF7), poly(9,9-dioctylfluorene) (PF8), poly(9,9-dinonylfluorene) (PF9), and poly(9,9-didecylfluorene) (PF10) in methylcyclohexane (MCH). After a heating−cooling cycle, in the 10−50 mg/mL concentration range, PF6/MCH, PF7/MCH, PF8/MCH, and PF9/MCH systems ...
Knaapila, M., Dias, F. B., Garamus, V. M., Almásy, L., Torkkeli, M., Leppänen, K., Galbrecht, F., Preis, E., Burrows, H. D., Scherf, U., Monkman, A. P.   +10 more
openaire   +1 more source

Structure–Performance Relationship Study of PMA Viscosity Index Improver in New Energy Vehicle Transmission Fluid

Lubricants
This study systematically investigates the structure–performance relationship of PMA (PolyMethacrylate) viscosity index improvers in new energy vehicle (NEV) transmission fluids. We developed an integrated analytical framework combining spectroscopic and
Jinglin Yin, Xiao Shi, Ling Lei, Jingsi Cao, Qianhui Zhao, Haipeng Zhao   +5 more
doaj   +1 more source

Controlling Grain Growth in Powder Bed Fusion of Yttria‐Stabilized Zirconia Using Femtosecond Lasers: Challenges and Methodological Insights

Advanced Engineering Materials, EarlyView.
Binder‐free laser powder bed fusion of 8YSZ with a femtosecond laser is used to map process windows linking scan strategy, heat accumulation, and grain growth. Time‐resolved thermography and simulations reveal thermal regimes that enable continuous, vitrified, and fine‐grained 8YSZ surface layers without absorptive additives and demonstrate ...
Markus Kühn, Sarah Kaden, Andrea Barz, Daniel Störzner, Jens Bliedtner, Andrés Fabián Lasagni   +5 more
wiley   +1 more source

Size Matters: Side Chain Length Affects SH2 Substrate Binding

Chemistry & Biology, 2010
The incorporation of lysine analogs in Src Homology 2 (SH2) domain variants by Virdee et al. (2010) reveals the length-dependent contribution of a single amino acid side chain in recognition of phosphotyrosine-containing substrate peptides and a change in specificity with shorter side chains.
openaire   +2 more sources

Influence of π-Conjugated Backbone Length and Tail Chain Number on Self-Assembly Structures of 4,6-Diamino-1,3,5-triazine Derivatives Revealed by STM

Chemistry
4,6-Diamino-1,3,5-triazine (DT) derivatives typically exhibit excellent liquid crystal properties, attracting numerous researchers interested in enhancing their performance.
Yi Wang, Fuqiong Wang, Xiaoyang Zhao, Zhipeng Zhang, Yue Huang, Hua Zheng, Xiaohong Cheng, Xinrui Miao   +7 more
doaj   +1 more source

The Role of Ultra‐Thin Passive Films and Organic Adsorbates on Aluminum Chips for a Friction‐Induced Solid‐State Recycling Process

Advanced Engineering Materials, EarlyView.
Despite benefits to storage stability and handleability of aluminum scrap, octadecyl phosphonic acid (ODPA) SAMs reduce the tensile strength of wires produced using friction‐induced recycling. Etching and methyl diphosphonic acid (MDPA) coatings, however, have little effect.
Timothy D. Goller, Steffen Gabsa, Werner Homberg, Guido Grundmeier   +3 more
wiley   +1 more source