Results 51 to 60 of about 792,156 (299)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Novel Design Flow for a Security-Driven Synthesis of Side-Channel Hardened Cryptographic Modules

Journal of Low Power Electronics and Applications, 2017
Over the last few decades, computer-aided engineering (CAE) tools have been developed and improved in order to ensure a short time-to-market in the chip design business.
Sorin A. Huss, Oliver Stein
doaj   +1 more source

An Automated End-to-End Side Channel Analysis Based on Probabilistic Model

Applied Sciences, 2020
In this paper, we propose a new automated way to find out the secret exponent from a single power trace. We segment the power trace into subsignals that are directly related to recovery of the secret exponent.
Jeonghwan Hwang, Ji Won Yoon
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Semi-Automatic Locating of Cryptographic Operations in Side-Channel Traces

Transactions on Cryptographic Hardware and Embedded Systems, 2021
Locating a cryptographic operation in a side-channel trace, i.e. finding out where it is in the time domain, without having a template, can be a tedious task even for unprotected implementations. The sheer amount of data can be overwhelming.
Jens Trautmann, Arthur Beckers, Lennert Wouters, Stefan Wildermann, Ingrid Verbauwhede, Jürgen Teich   +5 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Deep Learning-based Side Channel Attack on HMAC SM3.

International Journal of Interactive Multimedia and Artificial Intelligence, 2020
SM3 is a Chinese hash standard. HMAC SM3 uses a secret key to encrypt the input text and gives an output as the HMAC of the input text. If the key is recovered, adversaries can easily forge a valid HMAC.
Xin Jin, Yong Xiao, Shiqi Li, Suying Wang   +3 more
doaj   +1 more source

Virtual Analysis and Reduction of Side-Channel Vulnerabilities of Smartcards

, 2004
This paper focuses on the usability of the PINPAS tool. The PINPAS tool is an instruction-level interpreter for smartcard assembler languages, augmented with facilities to study side-channel vulnerabilities. The tool can simulate side-channel leakage and
den Hartog, Jerry, Dimitrakos, Theo, Martinelli, Fabio, Hartog, den, J.I., Dimitrakos, T., Martinelli, F., Vink, de, E.P., de Vink, Erik   +7 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source