Results 71 to 80 of about 2,530,127 (316)

Dermatological Side Effects of Sildenafil among a group of Iraqi Males

مجلة كلية الطب, 2011
Background: Sildenafil is a drug that is used to treat erectile dysfunctions, it acts by inhibiting CGMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis.
Nadheer A. Matloob
doaj   +1 more source

Cutaneous side-effects during therapy of melanoma by vemurafenib

, 2015
Introduction. Vemurafenib is a selective inhibitor of serine-threonine kinase BRAF used in the treatment of advanced melanoma with BRAF mutation. Effectiveness of this drug was confirmed in a large clinical trial, which led to the increase of its ...
Anna Ankudowicz, Bożena Wenska, Urszula Brzezicka-Ciach   +2 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Correlates of major medication side effects interfering with daily performance: results from a cross-sectional cohort study of older psychiatric patients

, 2015
Background: Polypharmacy is common among older persons who are also vulnerable to side effects. We aimed to characterize patients who on admission to a geriatric psychiatric hospital had major medication side effects interfering with daily performance ...
Bramness, Jørgen Gustav, Tveito, Marit, Refsum, Helge, Lorentzen, B., Høiseth, Gudrun, Bramness, J. G., Correll, Christoph U., Engedal, K., Engedal, Knut, Refsum, H., Lorentzen, Bernhard, Correll, C. U., Tveito, M., Hoiseth, G.   +13 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Prolactin Elevation Due to Sertraline Use in a Patient with Pituitary Adenoma: A Case Report

Ahi Evran Medical Journal
Antipsychotics are the drugs that most frequently cause prolactinemia among the psychiatric drug groups. When prolactin eleva tion is mentioned, it is generally considered as a side effect related to antipsychotics.
Meltem Puşuroğlu, Sefanur Köse, Cicek Hocaoglu   +2 more
doaj   +1 more source

The relationship of depressive symptoms in cancer patients with treatment by chemotherapy.

مجلة كلية الطب, 2009
Background: depressed mood and anxiety are common symptoms in hospitalized cancer patients .it is often presumed that anxiety and depression affect the occurrence and experience of physical symptoms .
Ali K. Khudhair
doaj   +1 more source

Side effects of Methylphenidate

, 2018
The thesis describes the variable Side effects of Methylphenidate, its mechanism of action, indications, contraindications and the possible positive and negative effects methylphenidate can induce in the human body, based on a wide review of 63 different
Mazor, Shabi
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source