Results 91 to 100 of about 13,350,898 (314)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Pathos, 2012 Opioid switching is a therapeutic procedure used in pain management as a method to improve analgesic response and/or reduce adverse side effects. The rationale behind opioid substitution is the incomplete cross-tolerance between opioid.
Carmelo Costa +2 more
doaj
South African Family Practice, 2008 Background: Adherence is the key to the effectiveness of antiretroviral therapy. However, many factors have been identified as facilitating or hampering adherence.
Ntambwe G. Malangu
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Psychotropic Drugs and Ocular Side Effects
Türk Oftalmoloji Dergisi, 2013 Nowadays the number of patients using the types of drugs in question here has significantly increased. A study carried out in relation with the long term use of psychotropic drugs shows that the consumption of this group of drugs has substantially ...
İpek Sönmez, Ümit Aykan
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Do antibiotics have side effects? [PDF]
Anytime antibiotics are used, they can cause side effects. When antibiotics aren\u2019t needed, they won\u2019t help you, and the side effects could still hurt you.
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Drug-Related Halitosis: A Narrative Review
International Dental JournalIntroduction: This article provides a current narrative review of the medications that may cause halitosis as a side effect. Halitosis is frequently associated with important social, psychological, and emotional aspects of life; therefore, it is crucial ...
Mina Iranitalab, Aviv Ouanounou
doaj +1 more source