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Targeting ST3GAL1 to downregulate ligands for the glycoimmune checkpoint Siglec-7 and reverse immune escape in hepatocellular carcinoma. [PDF]
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Siglec and anti-Siglec therapies
Current Opinion in Chemical Biology, 2021Siglecs (sialic acid-binding immunoglobulin-like lectins) are a family of receptors that bind sialic acids in specific linkages on glycoproteins and glycolipids. Siglecs play roles in immune signalling and exhibit cell-type specific expression and endocytic properties.
Paul R. Crocker, Gavuthami Murugesan
exaly +4 more sources
Siglec-5 and Siglec-14 mediate the endocytosis of ADAMTS13
Thrombosis Research, 2022The plasma metalloprotease ADAMTS13 regulates the thrombotic activity of the von Willebrand factor (VWF). ADAMTS13 is highly glycosylated and its carbohydrate chains are capped with sialic acid (SA). Thus, ADAMTS13 may interact with carbohydrate- and/or SA-binding plasma membrane receptors that are involved in the clearance of various plasma proteins ...
Masashi, Akiyama +2 more
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Molecular Aspects of Medicine, 2023
The term "allergic diseases" encompasses several common, IgE-mediated conditions that range from being annoying to those that are life-threatening. Available treatments include active avoidance of the instigating allergen and the use of a variety of oral, inhaled, intranasal, intraocular and injected agents.
Bruce S. Bochner +3 more
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The term "allergic diseases" encompasses several common, IgE-mediated conditions that range from being annoying to those that are life-threatening. Available treatments include active avoidance of the instigating allergen and the use of a variety of oral, inhaled, intranasal, intraocular and injected agents.
Bruce S. Bochner +3 more
openaire +2 more sources
Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. [PDF]
Glycobiology, 2007 Siglecs are vertebrate cell-surface receptors that recognize sialylated glycans. Here we have identified and characterized a novel Siglec, named Siglec-15. Siglec-15 is a type-I transmembrane protein consisting of: (i) two immunoglobulin (Ig)-like domains, (ii) a transmembrane domain containing a lysine residue, and (iii) a short cytoplasmic tail ...
Takashi Angata, Kazunori Nakamura
exaly +3 more sources
Gangliosides as Siglec ligands
Glycoconjugate Journal, 2023The structure of a sialoglycan can be translated into to a biological response when it binds to a specific endogenous lectin. Among endogenous sialic acid-binding lectins in humans are those comprising the 15-member Siglec family, most of which are expressed on overlapping sets of immune cells.
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Siglec-8 and Siglec-F, the new therapeutic targets in asthma
Immunopharmacology and Immunotoxicology, 2012The recruitment of eosinophils from the circulation into the airway is a prominent feature of allergic asthma. Persistent inflammatory responses may arise from inefficient mechanisms for resolution of inflammation, including delayed apoptosis. Several studies suggest that eosinophil apoptosis is delayed in asthma.
Alireza Razavi, Abbas Mirshafiey
exaly +3 more sources
Roles of Siglecs in neurodegenerative diseases
Molecular Aspects of Medicine, 2023Microglia are resident myeloid cells in the central nervous system (CNS) with a unique developmental origin, playing essential roles in developing and maintaining the CNS environment. Recent studies have revealed the involvement of microglia in neurodegenerative diseases, such as Alzheimer's disease, through the modulation of neuroinflammation. Several
Jian Jing Siew +3 more
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Impact of Siglecs on autoimmune diseases
Molecular Aspects of Medicine, 2023Autoimmune diseases affect tens of millions of people just in the United States alone. Most of the available treatment options are aimed at reducing symptoms but do not lead to cures. Individuals affected with autoimmune diseases suffer from the imbalance between tolerogenic and immunogenic functions of their immune system.
Katarzyna Alicja Brzezicka +1 more
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