Results 121 to 130 of about 1,197,707 (200)

Characterization of the Adherence of Clostridium difficile Spores: The Integrity of the Outermost Layer Affects Adherence Properties of Spores of the Epidemic Strain R20291 to Components of the Intestinal Mucosa [PDF]

, 2016
Indexación: Web of Science.Clostridium difficile is the causative agent of the most frequently reported nosocomial diarrhea worldwide. The high incidence of recurrent infection is the main clinical challenge of C. difficile infections (CBI). Formation of
Banawas, Saeed, Calderón, Iván, Castro-Córdova, Pablo, Fuentes, Juan A., Gil, Fernando, Miranda-Cárdenas, Camila, Mora-Uribe, Paola, Paredes-Sabja, Daniel, Rodas, Paula I., Sarker, Mahfuzur R.   +9 more
core   +2 more sources

Extracellular aspartic protease SAP2 of Candida albicans yeast cleaves human kininogens and releases proinflammatory peptides, Met-Lys-bradykinin and des-Arg(9)-Met-Lys-bradykinin [PDF]

, 2012
Bradykinin-related peptides, universal mediators of inflammation collectively referred to as the kinins, are often produced in excessive amounts during microbial infections.
Alexander Faussner, Andrzej Kozik, Barbasz, Carvalho, Gomes, Grazyna Bras, Ibeth Guevara-Lora, Kraus, Laemmli, Leeb, Maria Rapala-Kozik, Oehmcke, Oliwia Bochenska, Reddigari, Sainz, Sato, Zubakova   +16 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis [PDF]

, 2007
After injury, the CNS undergoes an astrocyte stress response characterized by reactive astrocytosis/proliferation, boundary formation, and increased glial fibrillary acidic protein (GFAP) and chondroitin sulfate proteoglycan (CSPG) expression. Previously,
Barnett, S.C., Fairless, R., Frame, M.C., Montague, P., Riddell, J.S., Santos-Silva, A., Smith, G.M., Toft, A.   +7 more
core   +3 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors.

PLoS ONE, 2018
Rivastigmine (Riv) is a potent and selective cholinesterase (acetylcholinesterase, AChE and butyrylcholinesterase, BuChE) inhibitor developed for the treatment of Alzheimer's disease (AD).
Kazuki Terada, Keisuke Migita, Yukari Matsushima, Yumi Sugimoto, Chiaki Kamei, Taichi Matsumoto, Masayoshi Mori, Kazuhisa Matsunaga, Jiro Takata, Yoshiharu Karube   +9 more
doaj   +1 more source

Broad-spectrum antiviral activity of the sigma-1 receptor antagonist PB28 against coronaviruses

Frontiers in Microbiology
The continuous evolution of coronaviruses poses persistent and severe threats to both human and animal health. While α- and β-coronaviruses mainly infect mammals, including humans, γ-coronaviruses predominantly infect poultry, causing substantial ...
Gaojie Song, Lingling Cheng, Lingling Cheng, Xingpeng Dong, Dapeng Li, Jia Cheng, Chao Shang, Xiao Li, Ran Zhu, Cuiling Zhang, Junwei Li   +10 more
doaj   +1 more source

Evaluation of Some Safety Parameters of Dual Histamine H₃ and Sigma-2 Receptor Ligands with Anti-Obesity Potential. [PDF]

Int J Mol Sci, 2023
Mika K, Szafarz M, Bednarski M, Siwek A, Szczepańska K, Kieć-Kononowicz K, Kotańska M.   +6 more
europepmc   +1 more source

Design and Synthesis of Orally Active Quinolyl Pyrazinamides as Sigma 2 Receptor Ligands for the Treatment of Pancreatic Cancer. [PDF]

J Med Chem, 2023
Roy J, Kyani A, Hanafi M, Xu Y, Takyi-Williams J, Sun D, Osman EEA, Neamati N.   +7 more
europepmc   +1 more source

Characterization of Sigma-2 Receptor-Specific Binding Sites Using [³H]DTG and [¹²⁵I]RHM-4. [PDF]

Pharmaceuticals (Basel), 2022
Weng CC, Riad A, Lieberman BP, Xu K, Peng X, Mikitsh JL, Mach RH.   +6 more
europepmc   +1 more source