Results 131 to 140 of about 1,197,707 (200)

Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation. [PDF]

Genes (Basel), 2022
Mavlyutov TA, Li J, Liu X, Shen H, Yang H, McCurdy CR, Pattnaik B, Guo LW.   +7 more
europepmc   +1 more source

Differential Responses to Sigma-1 or Sigma-2 Receptor Ablation in Adiposity, Fat Oxidation, and Sexual Dimorphism. [PDF]

Int J Mol Sci, 2022
Li J, Félix-Soriano E, Wright KR, Shen H, Baer LA, Stanford KI, Guo LW.   +6 more
europepmc   +1 more source

Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer. [PDF]

, 2017
Suppression of androgen receptor (AR) activity in prostate cancer by androgen depletion or direct AR antagonist treatment, although initially effective, leads to incurable castration-resistant prostate cancer (CRPC) via compensatory mechanisms including ...
Anderson, Kelsey N., Chen, Nan, Kania, Blase, Kim, Felix J., Knudsen, Karen E., Longen, Charles G., Maher, Christina M., Ostrander, William F., Oyer, Halley M., Salvino, Joseph M., Thomas, Jeffrey D.   +10 more
core   +1 more source

Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease. [PDF]

ACS Med Chem Lett, 2021
Rishton GM, Look GC, Ni ZJ, Zhang J, Wang Y, Huang Y, Wu X, Izzo NJ, LaBarbera KM, Limegrover CS, Rehak C, Yurko R, Catalano SM.   +12 more
europepmc   +1 more source

Editorial: Sigma Receptors

Frontiers in Pharmacology, 2020
Ebru Aydar, Enrique J. Cobos, Tangui Maurice, Ruth D. Murell-Lagnado, Stephen T. Safrany   +4 more
doaj   +1 more source

Dehydroepiandrosterone sulfate (DHEAS) is neuroprotective when administered either before or after injury in a focal cortical cold lesion model [PDF]

, 2006
Dehydroepiandrosterone and its sulfate (DHEAS) are sex hormone precursors that exert marked neurotrophic and/or neuroprotective activity in the central nervous system.
Dobszay B., Gábor, Farkas, Tamás, Juhász-Vedres, Gabriella, Kis, Zsolt, Párducz, Árpád, Rákos, Gabriella, Rózsa, Éva, Toldi, József, Wölfling, János   +8 more
core  

Identification and characterization of MAM03055A: A novel bivalent sigma-2 receptor/TMEM97 ligand with cytotoxic activity. [PDF]

Eur J Pharmacol, 2021
Liu CZ, Mottinelli M, Nicholson HE, McVeigh BM, Wong NK, McCurdy CR, Bowen WD.   +6 more
europepmc   +1 more source

QSAR-Based Computational Approaches to Accelerate the Discovery of Sigma-2 Receptor (S2R) Ligands as Therapeutic Drugs. [PDF]

Molecules, 2021
Yu Y, Dong H, Peng Y, Welsh WJ.
europepmc   +1 more source

The Sigma-2 Receptor/TMEM97 Agonist PB28 Suppresses Cell Proliferation and Invasion by Regulating the PI3K-AKT-mTOR Signalling Pathway in Renal Cancer. [PDF]

J Cell Mol Med, 2021
Zhan B, Zhang Z, Piao C, Dong X, Du Y, Kong C, Jiang Y.   +6 more
europepmc   +1 more source

Selectivity profile comparison for certain γ-butyrolactone and oxazolidinone-based ligands on a sigma 2 receptor over sigma 1: a molecular docking approach. [PDF]

RSC Adv, 2022
Bhandare RR, Sigalapalli DK, Shaik AB, Canney DJ, Blass BE.   +4 more
europepmc   +1 more source