Results 151 to 160 of about 1,197,707 (200)

NO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines. [PDF]

Cancers (Basel), 2020
Cantonero C, Camello PJ, Abate C, Berardi F, Salido GM, Rosado JA, Redondo PC.   +6 more
europepmc   +1 more source

Morphing of Ibogaine: A Successful Attempt into the Search for Sigma-2 Receptor Ligands. [PDF]

Int J Mol Sci, 2019
Floresta G, Dichiara M, Gentile D, Prezzavento O, Marrazzo A, Rescifina A, Amata E.   +6 more
europepmc   +1 more source

Neuroprotective Efficacy of a Sigma 2 Receptor/TMEM97 Modulator (DKR-1677) after Traumatic Brain Injury. [PDF]

ACS Chem Neurosci, 2019
Vázquez-Rosa E, Watson MR, Sahn JJ, Hodges TR, Schroeder RE, Cintrón-Pérez CJ, Shin MK, Yin TC, Emery JL, Martin SF, Liebl DJ, Pieper AA.   +11 more
europepmc   +1 more source

Differential gene expression by RNA-Seq in Sigma-2 Receptor/TMEM97 knockout cells reveals its role in complement activation and SARS-CoV-2 viral uptake

, 2021
Riad A, Aubert Y, Zeng C, Graham TJA, Petersson EJ, Capell BC, Mach RH.   +6 more
europepmc   +1 more source

A phase 1 clinical trial of the sigma-2 receptor complex allosteric antagonist CT1812, a novel therapeutic candidate for Alzheimer's disease. [PDF]

Alzheimers Dement (N Y), 2019
Grundman M, Morgan R, Lickliter JD, Schneider LS, DeKosky S, Izzo NJ, Guttendorf R, Higgin M, Pribyl J, Mozzoni K, Safferstein H, Catalano SM.   +11 more
europepmc   +1 more source

Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex. [PDF]

Sci Rep, 2018
Riad A, Zeng C, Weng CC, Winters H, Xu K, Makvandi M, Metz T, Carlin S, Mach RH.   +8 more
europepmc   +1 more source

S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands. [PDF]

J Cheminform, 2017
Nastasi G, Miceli C, Pittalà V, Modica MN, Prezzavento O, Romeo G, Rescifina A, Marrazzo A, Amata E.   +8 more
europepmc   +1 more source

Norbenzomorphan Framework as a Novel Scaffold for Generating Sigma 2 Receptor/PGRMC1 Subtype-Selective Ligands. [PDF]

ChemMedChem, 2016
Sahn JJ, Hodges TR, Chan JZ, Martin SF.
europepmc   +1 more source

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Sigma-2 Receptor as a Potential Drug Target

Current Medicinal Chemistry, 2021
Sigma-2 receptor plays key roles in promoting tumor cell apoptosis, enhancing efficacy of anti-tumor drugs, blocking signal transduction controlled by Aβ oligomers, regulating Ca2+ homeostasis and protecting nerve cells. Studies indicated that sigma-2 receptor may be closely coupled with ROS, LDL, mTOR, RAS, PLC/PKC, lysosomal autophagy and ...
Ai-Fang Chen, Wen-Hui Ma, Xiao-Yang Xie, Yun-Sheng Huang   +3 more
openaire   +2 more sources