Results 161 to 170 of about 1,197,707 (200)
Some of the next articles are maybe not open access.
Sigma-2 Receptor Ligands: Neurobiological Effects
Current Medicinal Chemistry, 2015Sigma-2 receptor is a widely distributed protein, which can modulate cell proliferation and involved in the pathogenesis of tumor. Photoaffinity labelling techniques testified that its molecular size is about 18 kDa. Recent studies indicated that sigma-2 receptor modulates the cytosolic Ca2+ concentration, dopaminergic transmission, and cocaine-induced
Lin, Guo, Xuechu, Zhen
openaire +2 more sources
Sigma‐2 receptor agonists kill lens epithelial cells
Acta Ophthalmologica, 2010Abstract Purpose The aim of the present study was to examine the effects of the sigma‐2 receptor agonist, siramesine, on morphology, growth, cell death, lysosomal function, and effects on extra‐lysosomal proteolytic systems in human lens epithelial cells.
JO KARLSSON +3 more
openaire +1 more source
Sigma-2 Receptor Expression in Bovine Papillomavirus-Associated Urinary Bladder Tumours
Journal of Comparative Pathology, 2010The expression of sigma-2 receptors was investigated in nine urothelial tumours of the urinary bladder of cattle. Each tumour was associated with the presence of DNA of bovine papillomavirus type-2 (BPV-2) and expression of the E5 viral oncoprotein.
ROPERTO, SANTE +11 more
openaire +3 more sources
Current development of sigma-2 receptor radioligands as potential tumor imaging agents
Bioorganic Chemistry, 2021Sigma receptors are transmembrane proteins with two different subtypes: σ1 and σ2. Because of its overexpression in tumors, the σ2 receptor (σ2R) is a well-known biomarker for cancer cells. A large number of small-molecule ligands for the σ2Rs have been identified and tested for imaging the proliferative status of tumors using single photon emission ...
Zahra, Shaghaghi +4 more
openaire +2 more sources
Sigma-2 Receptor: Past, Present and Perspectives on Multiple Therapeutic Exploitations
Future Medicinal Chemistry, 2018Identification of sigma-2 receptor (sig-2R) has been controversial. Nevertheless, interest in sig-2R is high for its overexpression in tumors and potentials in oncology. Additionally, sig-2R antagonists inhibit Aβ binding at neurons, blocking the cognitive impairments of Alzheimer's disease.
Abate, Carmen +2 more
openaire +3 more sources
Abstract 5281: Role of TMEM97/Sigma-2 receptor in prostate cancer
Cancer Research, 2023Abstract Introduction: Prostate cancer is the most common cancer in men. About one in eight men will be diagnosed with prostate cancer in his lifetime, and one in forty-one men will die of it. Sigma 2 receptor (σ2R) has been implicated in carcinogenesis including prostate cancer.
Xiangwei Fang +5 more
openaire +1 more source
Targeting Sigma-2 Receptor and ZFP91 in Pancreatic Cancer
2021Pancreatic cancer is one of the most aggressive malignancies with poor prognosis. The effectiveness of currently available conventional therapies is limited by chemoresistance and systemic toxicity. Thus, there is an urgent need to develop novel and effective anticancer agents by targeting critical pathways that drive tumorigenesis in pancreatic cancer.
openaire +2 more sources
Synthesis and evaluation of tetrahydroindazole derivatives as sigma-2 receptor ligands
Bioorganic & Medicinal Chemistry, 2015A series of tetrahydroindazole derivatives were synthesized and evaluated for their affinities for both sigma-1 and sigma-2 receptors. These compounds are hybrid structures of a tetrahydroindazole substituted benzamide and a 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety or a 9-azabicyclo[3.3.1]nonan-3-yl-amine moiety.
Zong-Wen, Wu +6 more
openaire +2 more sources
Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist
Biochemical Pharmacology, 2012Mast cells (MCs) are well known for their detrimental effects in the context of allergic disorders. Strategies that limit MC function can therefore have a therapeutic value. Previous studies have shown that siramesine, a sigma-2 receptor agonist originally developed as an anti-depressant, can induce cell death in transformed cells through a mechanism ...
Jane, Spirkoski +6 more
openaire +2 more sources
A selective sigma‐2 receptor ligand antagonizes cocaine‐induced hyperlocomotion in mice
Synapse, 2013ABSTRACTCocaine functions, in part, through agonist actions at sigma‐1 (σ1) receptors, while roles played by sigma‐2 (σ2) receptors are less established. Attempts to discriminate σ2receptor‐mediated effects of cocaine in locomotor hyperactivity assays have been hampered by the lack of potent and selective antagonists.
John R, Lever +7 more
openaire +2 more sources