Results 31 to 40 of about 1,197,707 (200)

TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death [PDF]

, 2019
Sigma-2 receptors have been implicated in both tumor proliferation and neurodegenerative diseases. Recently the sigma-2 receptor was identified as transmembrane protein 97 (TMEM97).
Hawkins, William G., Jin, Linda, Mach, Robert H., Makvandi, Mehran, Puentes, Laura, Riad, Aladdin, Schneider, Mark E., Jr., Weng, Chi-Chang, Xu, Kuiying, Zeng, Chenbo   +9 more
core   +3 more sources

Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy [PDF]

Autophagy, 2013
Autophagy resembles a recycling process in which proteins, organelles, or regions of the cytoplasm are enveloped and degraded. We have found that two of the central autophagy proteins, MAP1LC3 (microtubule-associated protein 1 light chain 3, also described as LC3) and UVRAG (UV radiation resistance associated/UV radiation associated gene), complex with
Shakeel U R, Mir, Steven R, Schwarze, Ling, Jin, Jinling, Zhang, Woodrow, Friend, Sumitra, Miriyala, Daret, St Clair, Rolf J, Craven   +7 more
openaire   +2 more sources

Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer [PDF]

, 2017
Background Despite considerable efforts by scientific research, pancreatic cancer is the fourth leading cause of cancer related mortalities.
Abate, Carmen, Berardi, Francesco, Hawkins, William, Hornick, John R, Niso, Mauro, Pati, Maria Laura, Spitzer, Dirk   +6 more
core   +2 more sources

PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships

Frontiers in Pharmacology, 2020
These unprecedented times have forced the scientific community to gather to face the COVID-19 pandemic. Efforts in diverse directions have been made. A multi-university team has focused on the identification of the host (human) proteins interacting with ...
Carmen Abate, Mauro Niso, Francesca Serena Abatematteo, Marialessandra Contino, Nicola Antonio Colabufo, Francesco Berardi   +5 more
doaj   +1 more source

Study of the Relationship between Sigma Receptor Expression Levels and Some Common Sigma Ligand Activity in Cancer Using Human Cancer Cell Lines of the NCI-60 Cell Line Panel

Biomedicines, 2021
Sigma (σ) receptors have attracted great interest since they are implicated in various cellular functions and biological processes and diseases, including various types of cancer. The receptor family consists of two subtypes: sigma-1 (σ1) and sigma-2 (σ2)
Evangelia Sereti, Chrisiida Tsimplouli, Elisavet Kalaitsidou, Nikos Sakellaridis, Konstantinos Dimas   +4 more
doaj   +1 more source

Contribution of Lysosome and Sigma Receptors to Neuroprotective Effects of Memantine Against Beta-Amyloid in the SH-SY5Y Cells [PDF]

Advanced Pharmaceutical Bulletin, 2020
Purpose: Memantine is an approved drug for the treatment of Alzheimer’s disease (AD). Autophagy, lysosome dysfunction, and sigma receptors have possible roles in the pathophysiology of AD.
Mojtaba Keshavarz, Majid Reza Farrokhi, Elahe Amirinezhad Fard, Mohammad Mehdipour   +3 more
doaj   +1 more source

Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating [PDF]

PeerJ, 2021
SARS-CoV-2 infects cardiac cells and causes heart dysfunction. Conditions such as myocarditis and arrhythmia have been reported in COVID-19 patients.
José Alexandre Salerno, Thayana Torquato, Jairo R. Temerozo, Livia Goto-Silva, Karina Karmirian, Mayara A. Mendes, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Letícia R Q. Souza, Isis M. Ornelas, Carla P. Veríssimo, Luiz Guilherme H S. Aragão, Gabriela Vitória, Carolina S G. Pedrosa, Suelen da Silva Gomes Dias, Vinicius Cardoso Soares, Teresa Puig-Pijuan, Vinícius Salazar, Rafael Dariolli, Diogo Biagi, Daniel R. Furtado, Luciana Barreto Chiarini, Helena L. Borges, Patrícia T. Bozza, Marilia Zaluar P. Guimarães, Thiago M.L. Souza, Stevens K. Rehen   +26 more
doaj   +2 more sources

Sigma-2 ligands induce tumour cell death by multiple signalling pathways [PDF]

, 2012
BACKGROUND: The sigma-2 receptor has been identified as a biomarker of proliferating cells in solid tumours. In the present study, we studied the mechanisms of sigma-2 ligand-induced cell death in the mouse breast cancer cell line EMT-6 and the human ...
Chang, Katherine, Chu, Wenhua, Hotchkiss, Richard S, Mach, Robert H, Pan, Fenghui, Rothfuss, Justin M, Tu, Zhude, Vangveravong, Suwanna, Zeng, Chenbo, Zhang, Jun   +9 more
core   +2 more sources

The Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum

Frontiers in Pharmacology, 2017
Drug addiction is a chronic, debilitating disease that affects millions of people around the world causing a substantial societal burden. Despite decades of research efforts, treatment possibilities remain limited and relapse represents the most ...
Anna M. Klawonn, Anna Nilsson, Carl F. Rådberg, Sarah H. Lindström, Mia Ericson, Björn Granseth, David Engblom, Michael Fritz   +7 more
doaj   +1 more source

The Roles of Intracellular Chaperone Proteins, Sigma Receptors, in Parkinson’s Disease (PD) and Major Depressive Disorder (MDD)

Frontiers in Pharmacology, 2019
Sigma receptors, including Sigma-1 receptors and Sigma-2 receptors, are highly expressed in the CNS. They are intracellular chaperone proteins. Sigma-1 receptors localize mainly at the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM ...
Kai Yang, Changcai Wang, Taolei Sun, Taolei Sun   +3 more
doaj   +1 more source