Results 41 to 50 of about 1,197,707 (200)
Quo vadis PGRMC? Grand-Scale Biology in Human Health and Disease
Frontiers in Bioscience-Landmark, 2022 The title usage of Latin Quo vadis ‘where are you going’ extends the question Unde venisti from where ‘did you come?’ posed in the accompanying paper and extends consideration of how ancient eukaryotic and eumetazoan functions of progesterone receptor ...
Michael A. Cahill
doaj +1 more source
Quantum Dot Based Luminescent Nanoprobes for Sigma-2 Receptor Imaging
Molecular Pharmaceutics, 2017 The increasing importance of sigma-2 receptor as target for the diagnosis and therapy of tumors paves the way for the development of innovative optically traceable fluorescent probes as tumor cell contrast and therapeutic agents. Here, a novel hybrid organic-inorganic nanostructure is developed by combining the superior fluorescent properties of ...
Maria Laura Pati +10 more
openaire +3 more sources
Idazoxan does not prevent but worsens focal hypoxic-ischemic brain damage in neonatal Wistar rats [PDF]
, 1999 We examined the neuroprotective efficacy of a post-treatment with idazoxan (Idaz): an alpha2-adrenoceptor antagonist with activity at the I1- and I2-subtypes of the imidazoline receptor (I-receptor), in an experimental model of perinatal hypoxic-ischemic
D. Antier, F. Franconi, F. Sannajust
core +2 more sources
Sigma-2 receptors as a biomarker of proliferation in solid tumours [PDF]
British Journal of Cancer, 2000 Over the past several years, our group has provided considerable evidence that the expression of sigma-2 (sigma2) receptors may serve as a biomarker of tumour cell proliferation. In these in vitro studies, sigma2 receptors were expressed 8-10 times more in proliferative (P) tumour cells than in quiescent (Q) tumour cells, and the extent and kinetics of
Wheeler, K T +6 more
openaire +2 more sources
Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine [PDF]
, 2015 Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior.
Aguinaga, David +17 more
core +1 more source
An Evaluation of the Relationship between Sigma-1 and Sigma-2 Receptors and the Endocannabinoid System [PDF]
, 2016 Within the past two decades, sigma receptors have become a popular area for research. Although much has been learned about their structure, subtypes, and functions; there is still much to be learned.
Miller, Jenn
core +12 more sources
PLoS ONE, 2012 In addition to both the α1 adrenergic receptor and N-methyl-D-aspartate (NMDA) receptor antagonists, ifenprodil binds to the sigma receptor subtypes 1 and 2.
Tamaki Ishima, Kenji Hashimoto
doaj +1 more source
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. [PDF]
, 2008 Mammalian Toll-like receptors (TLRs) 3, 7, 8 and 9 initiate immune responses to infection by recognizing microbial nucleic acids; however, these responses come at the cost of potential autoimmunity owing to inappropriate recognition of self nucleic acids.
Barton, Gregory M +6 more
core +2 more sources
Molecular Cancer, 2007 Background Resistance to modern adjuvant treatment is in part due to the failure of programmed cell death. Therefore the molecules that execute the apoptotic program are potential targets for the development of anti-cancer therapeutics.
Johnston Fabian +11 more
doaj +1 more source
Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer [PDF]
, 2013 BACKGROUND: The sigma-2 receptor has been validated as a biomarker for proliferating tumours. Second mitochondria-derived activator of caspase (Smac) is a protein released from mitochondria into the cytosol, leading to apoptosis.
A Jemal +44 more
core +2 more sources