Results 251 to 260 of about 1,199,100 (293)
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The sigma 1 receptor: A local media influencer
Cell Calcium, 2021The endoplasmic reticulum (ER) Ca2+ store contains many rapidly differentiable subdomains with specialized signaling properties. Recent work highlights how an integral ER membrane protein - the sigma 1 receptor (S1R) - nucleates local formation of cholesterol-rich ER subdomains.
Claudia M, Rohr, Jonathan S, Marchant
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Sigma-1 receptor and inflammatory pain
Inflammation Research, 2015The sigma-1 receptor (Sig-1R) is a unique ligand-regulated molecular chaperone that interacts with several protein targets such as G protein-coupled receptors and ion channels to modulate their activity. Sig-1R is located in areas of the central and peripheral nervous system that are key to pain control.
Georgia, Gris +3 more
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Novel sigma receptor ligands 1.
Bioorganic & Medicinal Chemistry Letters, 1993Abstract The preparation and SAR of the series of substituted 3(2H)-furanones which demonstrate potent selective binding to the sigma ligand binding site are reported.
S.R. Schow, S.W. Tam
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2017
There is a critical need for new analgesics acting through new mechanisms of action, which could increase the efficacy respect to existing therapies and/or reduce their unwanted effects. Current preclinical evidence supports the modulatory role of the sigma-1 receptor (σ1R) in nociception, mainly based on the pain-attenuated phenotype of σ1R knockout ...
Manuel, Merlos +4 more
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There is a critical need for new analgesics acting through new mechanisms of action, which could increase the efficacy respect to existing therapies and/or reduce their unwanted effects. Current preclinical evidence supports the modulatory role of the sigma-1 receptor (σ1R) in nociception, mainly based on the pain-attenuated phenotype of σ1R knockout ...
Manuel, Merlos +4 more
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Focus on Molecules: the Sigma-1 Receptor
Experimental Eye Research, 2005The Sigma-1 receptor (accession number NP 005857) has no known homology with other receptors and in fact most closely resembles a C-8,7 sterol isomerase found in fungi (Hayashi and Su, 2003). The gene encodes a protein consisting of 223 amino acids with two transmembrane spanning domains and a typical argenine-argenine (R–R) endoplasmic reticulum (ER ...
Duncan, George, Wang, Lixin
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Sigma-1 Receptor in Motoneuron Disease
2017Amyotrophic Lateral Sclerosis (ALS ) is a neurodegenerative disease affecting spinal cord and brain motoneurons , leading to paralysis and early death. Multiple etiopathogenic mechanisms appear to contribute in the development of ALS , including glutamate excitotoxicity, oxidative stress , protein misfolding, mitochondrial defects, impaired axonal ...
Mancuso, Renzo, Navarro, Xavier
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Bioorganic & Medicinal Chemistry Letters, 2016
Analogues of the decahydrobenzoquinolin-5-one class of sigma (σ) receptor ligands were used to probe the structure-activity relationship trends for this recently discovered series of σ ligands. In all, 29 representatives were tested for σ and opioid receptor affinity, leading to the identification of compounds possessing improved σ1 selectivity and ...
Michael C, McLeod +2 more
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Analogues of the decahydrobenzoquinolin-5-one class of sigma (σ) receptor ligands were used to probe the structure-activity relationship trends for this recently discovered series of σ ligands. In all, 29 representatives were tested for σ and opioid receptor affinity, leading to the identification of compounds possessing improved σ1 selectivity and ...
Michael C, McLeod +2 more
openaire +2 more sources