Results 121 to 130 of about 2,430,073 (342)
Molecular Oncology, EarlyView.Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu +3 more
wiley +1 more source
Model companion of ordered theories with an automorphism [PDF]
arXiv, 2013 Kikyo and Shelah showed that if $T$ is a theory with the Strict Order Property in some first-order language $\mathcal{L}$, then in the expanded language $\mathcal{L}_\sigma := \mathcal{L}\cup\{\sigma\}$ with a new unary function symbol $\sigma$, the bigger theory $T_\sigma := T\cup\{``\sigma \mbox{is an} \mathcal{L}\mbox{-automorphism''}\}$ does not ...
arxiv
Molecular Oncology, EarlyView.Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam +2 more
wiley +1 more source
Quark level linear σmodel (LσM) via loop graphs [PDF]
arXiv, 2000 First, the L\sigma M is nonperturbatively solved via loop-order gap equations. Then the Nambu-Goldstone theorem (NGT) is expressed in L\sigma M language. Next, the Lee null tadpole sum for this SU(2) L\sigma M theory is shown to require N_c = 3. Then L\sigma M s-wave chiral cancellations are studied in tree-and in loop-order.
arxiv
SUPERSYMMETRIC SIGMA MODELS [PDF]
, 1985 We begin to construct the most general supersymmetric Lagrangians in one, two and four dimensions. We find that the matter couplings have a natural interpretation in the language of the nonlinear sigma model.
openaire +1 more source
Dual Pairs of Gauged Linear Sigma Models and Derived Equivalences of Calabi-Yau threefolds
, 2017 In this work we study the phase structure of skew symplectic sigma models, which are a certain class of two-dimensional N = (2,2) non-Abelian gauged linear sigma models.
Gerhardus, Andreas, Jockers, Hans
core +1 more source
Molecular Oncology, EarlyView.VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa +13 more
wiley +1 more source