Results 111 to 120 of about 1,912,516 (286)

Tearing-mediated Alfvénic Turbulence in a Relativistic Plasma

open access: yesThe Astrophysical Journal
In astrophysical relativistic plasmas, Alfvénic turbulence exists across a wide range of scales. Similar to a nonrelativistic case, this turbulence can be influenced by the tearing instability.
Stanislav Boldyrev, Nuno F. Loureiro
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

open access: yesFEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta   +7 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

Targeting Sigma-1 and Sigma-2 Receptors in Neuropathic Pain: Pharmacology, Ligand Development, and Translational Progress

open access: yesBrain Sciences
Background: Neuropathic pain remains a major unmet clinical challenge. Growing evidence identifies sigma receptors (σRs) as pivotal intracellular modulators of maladaptive stress signaling, positioning them as promising non-opioid targets for chronic ...
Carlo Reale   +3 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

open access: yesFEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki   +5 more
wiley   +1 more source

Sigma\u27s collaboration: Our record of progress and the work ahead at the United Nations [PDF]

open access: yes, 2019
Sigma Theta Tau International holds Special consultative status with the United Nations. This presentation will inform members of what we have achieved by our relationship with United Nations, how our work has been accomplished, the relevance of the work
Schafer, Rebecca L.
core   +1 more source

Nonminimally coupled dark matter in clusters of galaxies: a fully comprehensive analysis

open access: yesEuropean Physical Journal C: Particles and Fields
In this study, we explore how a non-minimal coupling between dark matter and gravity can affect the behavior of dark matter in galaxy clusters. We have considered the case of a disformal coupling, which leads to a modification of the Poisson equation ...
Saboura Zamani   +2 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

open access: yesFEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Sigma Tools to Work Smarter, Not Harder [PDF]

open access: yes
Do you know and understand all the free tools and resources Sigma has available to you as a chapter leader? Sigma staff will show you how to use these items to work smarter!
Washum-Beye, Myra, Rogers, Katherine
core   +1 more source

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