Results 91 to 100 of about 813,237 (289)

Nearby early-type galaxies with ionized gas. The UV emission from GALEX observations

, 2010
We present GALEX far-ultraviolet (FUV, $\lambda_{eff}$=1538 \AA) and near-ultraviolet (NUV, $\lambda_{eff}$=2316 \AA) surface photometry of 40 early-type galaxies (ETGs) selected from a wider sample of 65 nearby ETGs showing emission lines in their ...
A. Bressan, A. Marino, Adelman-McCarthy, Andredakis, Annibali, Annibali, Annibali, Baldwin, Bertola, Bianchi, Bianchi, Bournaud, Bressan, Brown, Buta, Caon, Cappellari, Cardelli, Chapman, Clemens, Clemens, Coenda, Colbert, De Lucia G. Springel V.White, de Vaucouleurs, Donas, F. Annibali, Ferreras, Franx, Gil de Paz, Goudfrooij, Grossi, Heckman, Jedrzejewski, Jeong, Jeong, Kewley, Kewley, Kormendy, Krajnović, L. Bianchi, L.M. Buson, Laurikainen, Li, M. S. Clemens, Macchetto, Malin, Marino, Marino, Martin, McDermid, Morrissey, Neff, P. Panuzzo, Phillips, Piotto, Prugniel, R. Rampazzo, Rampazzo, Rampazzo, Reduzzi, Rogers, Sandage, Sandage, Sarzi, Schawinski, Sersic, Suh, Tal, Terlevich, Thilker, Thilker, Thomas, Treu, Tully, van Gorkom, W. W. Zeilinger, Wada, Werk, Yan, Yi, Yi, Zabludoff   +82 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The sigma profile: A formal tool to study organization and its evolution at multiple scales [PDF]

Complexity, 2010
The $ $ profile is presented as a tool to analyze the organization of systems at different scales, and how this organization changes in time. Describing structures at different scales as goal-oriented agents, one can define $ \in [0,1]$ ("satisfaction") as the degree to which the goals of each agent at each scale have been met.
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Machine‐Learning Analysis of Streptomyces coelicolor Transcriptomes Reveals a Transcription Regulatory Network Encompassing Biosynthetic Gene Clusters

Advanced Science
Streptomyces produces diverse secondary metabolites of biopharmaceutical importance, yet the rate of biosynthesis of these metabolites is often hampered by complex transcriptional regulation.
Yongjae Lee, Donghui Choe, Bernhard O. Palsson, Byung‐Kwan Cho   +3 more
doaj   +1 more source

Discovery of Novel Benzamide-Based Sigma-1 Receptor Agonists with Enhanced Selectivity and Safety

Molecules
Central nervous system (CNS) disorders such as neurodegenerative diseases, multiple sclerosis, or even brain ischemia represent major therapeutic challenges with limited effective treatments. The sigma-1 receptor (S1R), a unique ligand-operated molecular
Pascal Carato, Bénédicte Oxombre, Séverine Ravez, Rajaa Boulahjar, Marion Donnier-Maréchal, Amélie Barczyk, Maxime Liberelle, Patrick Vermersch, Patricia Melnyk   +8 more
doaj   +1 more source

Optical and physical properties of aerosols in the boundary layer and free troposphere over the Amazon Basin during the biomass burning season [PDF]

Atmospheric Chemistry and Physics, 2006
As part of the Large Scale Biosphere-Atmosphere Experiment in Amazonia – Smoke, Aerosols, Clouds, Rainfall and Climate (LBA-SMOCC) campaign, detailed surface and airborne aerosol measurements were performed over the Amazon Basin during the dry to ...
D. Chand, D. Chand, P. Guyon, P. Artaxo, O. Schmid, O. Schmid, G. P. Frank, L. V. Rizzo, O. L. Mayol-Bracero, L. V. Gatti, M. O. Andreae   +10 more
doaj  

Origin of structural and kinematical properties of the Small Magellanic Cloud

, 2009
We investigate structural, kinematical, and chemical properties of stars and gas in the Small Magellanic Cloud (SMC) interacting with the Large Magellanic Cloud (LMC) and the Galaxy based on a series of self-consistent chemodynamical simulations.
Bekki, Binney, Broeils, Brüns, Cioni, Hatzidimitriou, Idiart, Kato, Kenji Bekki, Masashi Chiba, Monaghan, Murai, Noguchi, Spite   +13 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source