Results 91 to 100 of about 1,912,516 (286)

Resource paper on global health and nursing research priorities [PDF]

, 1905
It is recommended that Sigma Theta Tau International accept the following list of research priorities to guide its decision-making during the next biennium: promotion of healthy communities through health promotion, disease prevention and recognition of ...
Sigma Theta Tau International
core  

Machine‐Learning Analysis of Streptomyces coelicolor Transcriptomes Reveals a Transcription Regulatory Network Encompassing Biosynthetic Gene Clusters

Advanced Science
Streptomyces produces diverse secondary metabolites of biopharmaceutical importance, yet the rate of biosynthesis of these metabolites is often hampered by complex transcriptional regulation.
Yongjae Lee, Donghui Choe, Bernhard O. Palsson, Byung‐Kwan Cho   +3 more
doaj   +1 more source

Discovery of Novel Benzamide-Based Sigma-1 Receptor Agonists with Enhanced Selectivity and Safety

Molecules
Central nervous system (CNS) disorders such as neurodegenerative diseases, multiple sclerosis, or even brain ischemia represent major therapeutic challenges with limited effective treatments. The sigma-1 receptor (S1R), a unique ligand-operated molecular
Pascal Carato, Bénédicte Oxombre, Séverine Ravez, Rajaa Boulahjar, Marion Donnier-Maréchal, Amélie Barczyk, Maxime Liberelle, Patrick Vermersch, Patricia Melnyk   +8 more
doaj   +1 more source

Optical and physical properties of aerosols in the boundary layer and free troposphere over the Amazon Basin during the biomass burning season [PDF]

Atmospheric Chemistry and Physics, 2006
As part of the Large Scale Biosphere-Atmosphere Experiment in Amazonia – Smoke, Aerosols, Clouds, Rainfall and Climate (LBA-SMOCC) campaign, detailed surface and airborne aerosol measurements were performed over the Amazon Basin during the dry to ...
D. Chand, D. Chand, P. Guyon, P. Artaxo, O. Schmid, O. Schmid, G. P. Frank, L. V. Rizzo, O. L. Mayol-Bracero, L. V. Gatti, M. O. Andreae   +10 more
doaj  

Empirical Models for Dark Matter Halos. II. Inner profile slopes, dynamical profiles, and rho/sigma^3

, 2006
We have recently shown that both the Prugniel-Simien model and Sersic's function (hereafter referred to as the Einasto model when applied to internal density profiles) describe simulated dark matter halos better than an NFW-like model with equal number of parameters. Here we provide analytical expressions for the logarithmic slopes of these models, and
Graham, Alister W., Merritt, David, Moore, Ben, Diemand, Juerg, Terzic, Balsa   +4 more
openaire   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

The Safety Profile of Pridopidine, a Novel Sigma-1 Receptor Agonist for the Treatment of Huntington’s Disease

CNS Drugs
Huntington's disease (HD) is a rare, fatal, chronic progressive neurodegenerative disorder with a significant unmet medical need for effective treatments. Pridopidine is a novel, first-in-class, highly selective and potent sigma-1 receptor (S1R) agonist in development for HD. Pridopidine has been extensively studied in adult HD across the full spectrum
Yigal Paul Goldberg, Leehee Navon-Perry, Andrés Cruz-Herranz, Kelly Chen, Gabriele Hecker-Barth, Katrin Spiegel, Yael Cohen, Martin Niethammer, Andrew M. Tan, Henk Schuring, Michal Geva, Michael R. Hayden   +11 more
openaire   +2 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Prediction of Activity and Selectivity Profiles of Sigma Receptor Ligands Using Machine Learning Approaches

Journal of Chemical Information and Modeling
Sigma (σ) receptors (SRs) have emerged as important therapeutic targets due to their roles in various biological pathways. They are classified into two subtypes: S1R, primarily distributed in the central nervous system and related to neuroprotection and neurodegenerative diseases, and S2R mainly expressed in cancer cells and associated with cell ...
Lisa Lombardo, Verena Battisti, Thierry Langer, Rosaria Gitto, Laura De Luca   +4 more
openaire   +4 more sources

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source