Results 71 to 80 of about 813,237 (289)

Empirical Models for Dark Matter Halos. II. Inner profile slopes, dynamical profiles, and rho/sigma^3

, 2006
We have recently shown that both the Prugniel-Simien model and Sersic's function (hereafter referred to as the Einasto model when applied to internal density profiles) describe simulated dark matter halos better than an NFW-like model with equal number of parameters. Here we provide analytical expressions for the logarithmic slopes of these models, and
Graham, Alister W., Merritt, David, Moore, Ben, Diemand, Juerg, Terzic, Balsa   +4 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Viscoelastic performance evaluation of petrol oil and different macromolecule materials

International Journal of Thermofluids
This study involved conducting an experimental investigation into the flow properties of different petrol oil–macromolecule material emulsions with regard to their viscous and elastic behaviors to assess the performance of the two most used polymers ...
Mamdouh Ghannam, Mohamed Y.E. Selim
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The L-sigma Relation of Local HII Galaxies

, 2011
We present for the first time a new data set of emission line widths for 118 star-forming regions in HII galaxies (HIIGs). This homogeneous set is used to investigate the L-sigma relation in conjunction with optical spectrophotometric observations ...
Arsenault, Bordalo, Brosche, Bujarrabal, Campbell, Cohen, E. Telles, Erb, Fairall, François, Fuentes-Masip, García-Díaz, Hippelein, Izotov, Izotov, Jolliffe, Kehrig, Kniazev, Kunth, Law, Lequeux, Lowenthal, Markarian, Martínez-Delgado, Mas-Hesse, Maza, Maíz-Apellániz, Melnick, Melnick, Melnick, Melnick, Miesch, Osterbrock, Pagel, Pena, Pettini, Pilyugin, Plionis, Plionis, Riess, Salzer, Stasińska, Telles, Telles, Tenorio-Tagle, Terlevich, Terlevich, V. Bordalo, van Zee, Vílchez, Zwicky   +50 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Semi-empirical catalog of early-type galaxy-halo systems: dark matter density profiles, halo contraction and dark matter annihilation strength

, 2012
With SDSS galaxy data and halo data from up-to-date N-body simulations we construct a semi-empirical catalog (SEC) of early-type systems by making a self-consistent bivariate statistical match of stellar mass (M_star) and velocity dispersion (sigma) with
, A. Sonnenfeld ., A. Tasitsiomi, A.A. Klypin, A.B. Newman, A.C.C. Guimarães, A.R. Duffy ., A.V. Kravtsov ., A.V. Macciò ., A.W. Graham, Andrey V Kravtsov, B.P. Moster ., C. Conroy, D. Clowe ., D. Rusin, D.H. Rudd, F. Prada, F. Shankar, Fermi-LAT collaboration, G.L. Bryan, I. Jorgensen, I. Márquez, J. Binney, J. Einasto, J. Wolf ., J.-P. Kneib ., J.F. Navarro, J.L. Sérsic, Joshua A Frieman, K. Umetsu ., Kyu-Hyun Chae, L.V.E. Koopmans ., M. Ackermann ., M. Persic, M.W. Auger ., Mariangela Bernardi, O. Gerhard, O.Y. Gnedin, O.Y. Gnedin ., P. Prugniel, P.H. Johansson, P.S. Behroozi, R. Mandelbaum, R. Reyes ., S. Trujillo-Gomez, S.D.M. White, SDSS collaboration, SDSS collaboration, SDSS collaboration, T. Treu ., WMAP collaboration, X. Yang   +51 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Bearing capacity of steel thin-walled profiles in reliability assessment [PDF]

E3S Web of Conferences, 2019
The increasing use of light steel thin-walled structures is determined by the efficiency of the production of cold-formed profiles. However, there are problems of calculating the reliability of thin-walled structures.
Korsun Natalia, Prostakishina Daria
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source