Results 61 to 70 of about 1,912,516 (286)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

25th International Nursing Research Congress 2014 Conference Proceedings [PDF]

open access: yes, 2018
Sigma Theta Tau International the Honor Society of Nursing (Sigma) conducted its 25th International Nursing Research Congress at the Hong Kong Convention and Exhibition Centre, 24-28 July 2014.
Sigma Theta Tau International
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Toward enhanced quality assurance guidelines for deep hyperthermia devices: a multi-institution study

open access: yesInternational Journal of Hyperthermia
Introduction Hyperthermia efficacy depends on the temperatures achieved in the target area. Therefore, hyperthermia systems must deliver both controlled and conformal heating. This study presents a comprehensive multi-institutional quality assurance (QA)
Mattia De Lazzari   +5 more
doaj   +1 more source

Statistical Process Control for Monitoring Nonlinear Profiles: A Six Sigma Project on Curing Process [PDF]

open access: yesQuality Engineering, 2012
This article describes a successful Six Sigma project in the context of statistical engineering for integrating SPC, a statistical method, to the existing practice of engineering process control (EPC) according to science.
Chang, Shing I.   +4 more
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Viscoelastic performance evaluation of petrol oil and different macromolecule materials

open access: yesInternational Journal of Thermofluids
This study involved conducting an experimental investigation into the flow properties of different petrol oil–macromolecule material emulsions with regard to their viscous and elastic behaviors to assess the performance of the two most used polymers ...
Mamdouh Ghannam, Mohamed Y.E. Selim
doaj   +1 more source

Listeria monocytogenes σA Is Sufficient to Survive Gallbladder Bile Exposure

open access: yesFrontiers in Microbiology, 2019
Listeria monocytogenes is a foodborne Gram-positive bacterium causing listeriosis in both animals and humans. It can persist and grow in various environments including conditions countered during saprophytic or intra-host lifestyles. Sigma (σ) subunit of
Atsadang Boonmee   +2 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Definition of the σ(W) regulon of Bacillus subtilis in the absence of stress.

open access: yesPLoS ONE, 2012
Bacteria employ extracytoplasmic function (ECF) sigma factors for their responses to environmental stresses. Despite intensive research, the molecular dissection of ECF sigma factor regulons has remained a major challenge due to overlaps in the ECF sigma
Jessica C Zweers   +4 more
doaj   +1 more source

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