Results 51 to 60 of about 1,912,516 (286)

Developing deep learning-based large-scale organic reaction classification model via sigma-profiles

Green Chemical Engineering
Advanced technologies like deep learning have accelerated the discovery of novel chemical reactions, especially in the field of organic synthesis. With hundreds of thousands of reactions available for reference, one way to effectively leverage them is by
Wenlong Wang, Chenyang Xu, Jian Du, Lei Zhang   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Nursing Education Research Conference 2018 Conference Proceedings [PDF]

, 2018
Sigma Theta Tau International Honor Society of Nursing (Sigma) and the National League for Nursing (NLN) conducted the 2018 Nursing Education Research Conference in Washington, DC, April 19-21, with the theme of Generating and Translating Evidence for ...
Sigma Theta Tau International
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Pathway and Sigma partnership: Leveraging professional branding [PDF]

, 2022
The American Nurses Credentialing Center\u27s Pathway to Excellence® Program (Pathway) and Sigma Theta Tau International Honor Society of Nursing (Sigma) are harnessing their collective impact to grow in value and benefit nursing worldwide.
Dans, Maricon, Gray, Sarah E.
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Sigma nurses engagement with the sustainable development goals: A call to action [PDF]

, 2022
Over the last decade, Sigma chapters have been encouraged to incorporate the Sustainable Development Goals (SDGs) into their strategic and operational plans.
Chiu, Patrick, Mumba, Mercy N., Hawkins, Janice E.   +2 more
core   +1 more source

Homogenizing and estimating the uncertainty in NOAA's long-term vertical ozone profile records measured with the electrochemical concentration cell ozonesonde [PDF]

Atmospheric Measurement Techniques, 2018
NOAA's program of long-term monitoring of the vertical distribution of ozone with electrochemical concentration cell (ECC) ozonesondes has undergone a number of changes over the 50-year record.
C. W. Sterling, C. W. Sterling, B. J. Johnson, S. J. Oltmans, H. G. J. Smit, A. F. Jordan, A. F. Jordan, P. D. Cullis, P. D. Cullis, E. G. Hall, E. G. Hall, A. M. Thompson, J. C. Witte, J. C. Witte   +13 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Supporting universal access to affordable, quality health care [PDF]

, 2009
Honor Society of Nursing, Sigma Theta Tau International support for efforts to ensure access to equitable, affordable, quality health care services across the ...
Sigma Theta Tau International
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Exploring the role of sigma factor gene expression on production by Corynebacterium glutamicum: sigma factor H and FMN as example

Frontiers in Microbiology, 2015
Bacteria are known to cope with environmental changes by using alternative sigma factors binding to RNA polymerase core enzyme. Sigma factor is one of the targets to modify transcription regulation in bacteria and to influence production capacities.
Hironori eTaniguchi, Volker F. Wendisch
doaj   +1 more source

Structural properties of prokaryotic promoter regions correlate with functional features. [PDF]

PLoS ONE, 2014
The structural properties of the DNA molecule are known to play a critical role in transcription. In this paper, the structural profiles of promoter regions were studied within the context of their diversity and their function for eleven prokaryotic ...
Pieter Meysman, Julio Collado-Vides, Enrique Morett, Roberto Viola, Kristof Engelen, Kris Laukens   +5 more
doaj   +1 more source