Results 31 to 40 of about 1,912,516 (286)

Selectivity profile comparison for certain γ-butyrolactone and oxazolidinone-based ligands on a sigma 2 receptor over sigma 1: a molecular docking approach

RSC Advances, 2022
Selective action of γ-butyrolactones and oxazolidinones towards σ 2 receptor.
Richie R. Bhandare, Dilep Kumar Sigalapalli, Afzal B. Shaik, Daniel J. Canney, Benjamin E. Blass   +4 more
openaire   +3 more sources

Prediction of Hydrogen-Bonding Interaction Free Energies with Two New Molecular Descriptors

Liquids
This work is a continuation of our recent work on the prediction of hydrogen-bonding (HB) interaction enthalpies. In the present work, a simple method is proposed for the prediction of the HB interaction free energies.
William E. Acree, Costas Panayiotou
doaj   +1 more source

Spatiotemporal variability of water vapor investigated using lidar and FTIR vertical soundings above the Zugspitze [PDF]

Atmospheric Chemistry and Physics, 2015
Water vapor is the most important greenhouse gas and its spatiotemporal variability strongly exceeds that of all other greenhouse gases. However, this variability has hardly been studied quantitatively so far. We present an analysis of a 5-year period of
H. Vogelmann, R. Sussmann, T. Trickl, A. Reichert   +3 more
doaj   +1 more source

Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2)

BMC Genomics, 2008
Background A small "sigma-like" protein, AfsS, pleiotropically regulates antibiotic biosynthesis in Streptomyces coelicolor. Overexpression of afsS in S.
Sherman David H, Kyung Yun-Seung, Glod Frank, Mehra Sarika, Charaniya Salim, Jayapal Karthik P, Lian Wei, Hu Wei-Shou   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands [PDF]

Proceedings of the National Academy of Sciences, 2011
Reported biological activities of Stemona natural products, such as antitussive activity, inspired the development of synthetic methods to access several alkaloids within this family and in so doing develop a general route to the core skeleta shared by the class of natural products.
Kevin J, Frankowski, Vincent, Setola, Jon M, Evans, Ben, Neuenswander, Bryan L, Roth, Jeffrey, Aubé   +5 more
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Transforming the nursing landscape: Sigma Academies redefined [PDF]

, 2019
Sigma\u27s leadership academies have been educating nurses for more than 15 years with great success and outcomes. Now, as Sigma works to prepare the next generation of nurse leaders and faculty, a transformation has taken place.
Manning, Danielle Perkins, Howard, Matthew S., Vlasich, Cynthia, Beranek, Karen M.   +3 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Comparative Analysis of Mycoplasma gallisepticum vlhA Promoters

Frontiers in Genetics, 2018
Mycoplasma gallisepticum is an intracellular parasite affecting respiratory tract of poultry that belongs to class Mollicutes. M. gallisepticum features numerous variable lipoprotein hemagglutinin genes (vlhA) that play a role in immune escape.
Mikhail Orlov, Irina Garanina, Gleb Y. Fisunov, Anatoly Sorokin   +3 more
doaj   +1 more source