Results 101 to 110 of about 813,237 (289)

Characterization of anomalous Zeeman patterns in complex atomic spectra

, 2012
The modeling of complex atomic spectra is a difficult task, due to the huge number of levels and lines involved. In the presence of a magnetic field, the computation becomes even more difficult.
A. G. Shenstone, A. Jucys, A. R. Edmonds, B. R. Judd, D. A. Varshalovich, E. El-Baz, E. El-Baz, E. El-Baz, E. U. Condon, F. Paschen, Franck Gilleron, G. A. Korn, G. Mathys, G. Mathys, H. R. Griem, I. I. Sobelman, Jean-Christophe Pain, M. G. Kendall, P. Zeeman, R. C. Kirkpatrick, R. D. Cowan, R. Karazija, R. Karazija, R. Karazija, W. C. Martin, Y. Bordarier   +25 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Capturing the Cranio-Caudal Signature of a Turn with Inertial Measurement Systems: Methods, Parameters Robustness and Reliability

Frontiers in Bioengineering and Biotechnology, 2017
BackgroundTurning is a challenging mobility task requiring coordination and postural stability. Optimal turning involves a cranio-caudal sequence (i.e., the head initiates the motion, followed by the trunk and the pelvis), which has been shown to be ...
Karina Lebel, Karina Lebel, Hung Nguyen, Hung Nguyen, Christian Duval, Christian Duval, Réjean Plamondon, Patrick Boissy, Patrick Boissy   +8 more
doaj   +1 more source

Constraints on dark matter physics from dwarf galaxies through galaxy cluster haloes

, 2000
One of the predictions of the standard CDM is that dark haloes have centrally divergent density profiles. An extensive body of rotation curve observations of dwarf and low surface brightness galaxies shows the dark haloes of those systems to be ...
Avila-Reese, V., Chincarini, G., D'Onghia, E., Firmani, C., Hernandez, X.   +4 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Statistical mechanics of collisionless orbits. II. Structure of halos

, 2010
In this paper, we present the density, \rho, velocity dispersion, \sigma, and \rho/\sigma^3 profiles of isotropic systems which have the energy distribution, N(E)\propto[\exp(\phi_0-E)-1], derived in Paper I.
Austin, Bellovary, Binney, Binney, Hjorth, Hjorth, Jens Hjorth, Liliya L. R. Williams, Lynden-Bell, Madsen, Medvedev, Merritt, Merritt, Navarro, Stiavelli, Williams   +15 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Large eddy simulation of water flow over series of dunes

Water Science and Engineering, 2011
Large eddy simulation was used to investigate the spatial development of open channel flow over a series of dunes. The three-dimensional filtered Navier-Stokes (N-S) equations were numerically solved with the fractional-step method in sigma coordinates ...
Jun Lu, Ling-ling Wang, Hai Zhu, Hui-chao Dai   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Cloning and characterization of a novel sigma-like glutathione S-transferase from the giant panda parasitic nematode, Baylisascaris schroederi

Parasites & Vectors, 2015
Background Baylisascaris schroederi, an intestinal nematode of the giant panda, is the cause of the often fatal disease, baylisascariasis. Glutathione S-transferases (GSTs) are versatile enzymes that can affect parasite survival and parasite-host ...
Yue Xie, Xuan Zhou, Lin Chen, Zhihe Zhang, Chengdong Wang, Xiaobin Gu, Tao Wang, Xuerong Peng, Guangyou Yang   +8 more
doaj   +1 more source