Results 251 to 260 of about 1,201,382 (297)

Sigma Receptors and Cocaine Abuse

Current Topics in Medicinal Chemistry, 2011
Sigma receptors have been well documented as a protein target for cocaine and have been shown to be involved in the toxic and stimulant actions of cocaine. Strategies to reduce the access of cocaine to sigma receptors have included antisense oligonucleotides to the sigma-1 receptor protein as well as small molecule ligand with affinity for sigma ...
Sanju, Narayanan, Christophe, Mesangeau, Jacques H, Poupaert, Christopher R, McCurdy   +3 more
openaire   +2 more sources

Sigma Receptors and Cancer

Cancer Research, 2004
Abstract The sigma (σ) receptor and its agonists have been implicated in a myriad of cellular functions, biological processes and diseases. Whereas the precise molecular mechanism(s) of σ receptors and their involvement in cancer cell biology have not been elucidated, recent work has started to shed some light on these issues.
Ebru Aydar, Christopher P. Palmer, Mustafa B. A. Djamgoz   +2 more
openaire   +1 more source

Sigma-1 Receptor and Pain

2017
There is a critical need for new analgesics acting through new mechanisms of action, which could increase the efficacy respect to existing therapies and/or reduce their unwanted effects. Current preclinical evidence supports the modulatory role of the sigma-1 receptor (σ1R) in nociception, mainly based on the pain-attenuated phenotype of σ1R knockout ...
Manuel, Merlos, Luz, Romero, Daniel, Zamanillo, Carlos, Plata-Salamán, José Miguel, Vela   +4 more
openaire   +2 more sources

Sigma-2 Receptor Ligands: Neurobiological Effects

Current Medicinal Chemistry, 2015
Sigma-2 receptor is a widely distributed protein, which can modulate cell proliferation and involved in the pathogenesis of tumor. Photoaffinity labelling techniques testified that its molecular size is about 18 kDa. Recent studies indicated that sigma-2 receptor modulates the cytosolic Ca2+ concentration, dopaminergic transmission, and cocaine-induced
Lin, Guo, Xuechu, Zhen
openaire   +2 more sources

(Aminoalkoxy)chromones. Selective .sigma. receptor ligands

Journal of Medicinal Chemistry, 1992
A series of (aminoalkoxy)chromones has been prepared, members of which bind potently (16-100 nM) at the sigma binding site and bind weakly (greater than 1000 nM) at the dopamine D2 receptor and 33 other receptors, second messenger systems, and ion channels.
R H, Erickson, K J, Natalie, W, Bock, Z, Lu, F, Farzin, R G, Sherrill, D J, Meloni, R J, Patch, W J, Rzesotarski, J, Clifton   +9 more
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Sigma receptors in schizophrenic cerebral cortices

Neurochemical Research, 1992
Antipsychotics represent high affinity for sigma receptors and sigma-like drugs often have the psychotomimetic properties. Besides, the receptors are unevenly distributed in human brain. These findings suggest that sigma receptors might be involved in the pathophysiology of schizophrenia. Sigma receptors in rat and human brain were measured with [3H]-1,
H, Shibuya, H, Mori, M, Toru
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[Sigma (sigma) receptor and neurosteroids].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2000
Studies on the sigma receptor and related compounds are becoming more attractive since they were found to be closely related to higher brain functions such as memory, learning, depression, anxiety, schizophrenia and neuroprotection. Along with these pharmacological findings, the single transmembrane-type, non-metabotropic sigma binding protein has been
H, Ueda, A, Yoshida
openaire   +1 more source

Sigma receptors: biology and therapeutic potential

Psychopharmacology, 2004
More than 20 years after the identification of the sigma receptors as a unique binding site in the brain and in the peripheral organs, several questions regarding this receptor are still open. Only one of the subtypes of the receptor has been cloned to date, but the endogenous ligand still remains unknown, and the possible association of the receptor ...
Xavier, Guitart, Xavier, Codony, Xavier, Monroy   +2 more
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Sigma opioid receptor; SKF-10,047 update

Neuropeptides, 1985
We found that (-)-SKF-10,047 blocks EEG and behavioral effects of morphine in the naive rat, precipitates withdrawal in morphine-dependent rats, produces physical dependence as evidenced by naloxone-induced withdrawal, and displaces [3H] dihydromorphine from brain homogenates. (+)-SKF-10,047 did not produce dependence upon chronic treatment, and it did
N, Khazan, G A, Young, E E, el-Fakahany, O, Hong, D, Calligaro   +4 more
openaire   +2 more sources

Sigma-1 receptor and inflammatory pain

Inflammation Research, 2015
The sigma-1 receptor (Sig-1R) is a unique ligand-regulated molecular chaperone that interacts with several protein targets such as G protein-coupled receptors and ion channels to modulate their activity. Sig-1R is located in areas of the central and peripheral nervous system that are key to pain control.
Georgia, Gris, Enrique José, Cobos, Daniel, Zamanillo, Enrique, Portillo-Salido   +3 more
openaire   +2 more sources