Results 21 to 30 of about 1,201,382 (297)

Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels.

PLoS ONE, 2012
(+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors.
Xiao-Fei Gao, Jin-Jing Yao, Yan-Lin He, Changlong Hu, Yan-Ai Mei   +4 more
doaj   +1 more source

Negative Impact of Sigma-1 Receptor Agonist Treatment on Tissue Integrity and Motor Function Following Spinal Cord Injury

Frontiers in Pharmacology, 2021
In traumatic spinal cord injury, the initial trauma is followed by a cascade of impairments, including excitotoxicity and calcium overload, which ultimately induces secondary damages. The sigma-1 receptor is widely expressed in the central nervous system
Alise Lattard, Gaëtan Poulen, Gaëtan Poulen, Sylvain Bartolami, Yannick N. Gerber, Florence E. Perrin, Florence E. Perrin   +6 more
doaj   +1 more source

3D-QSAR and docking studies of pentacycloundecylamines at the sigma-1 (σ1) receptor [PDF]

, 2013
Pentacycloundecylamine (PCU) derived compounds have been shown to be promising lead structures for the development of novel drug candidates aimed at a variety of neurodegenerative and psychiatric diseases.
Ablordeppey, Cornelis J. Van der Schyf, Geldenhuys, Geldenhuys, Geldenhuys, Glennon, Hanner, Hawkins, Hawkins, Hayashi, Hayashi, Hellewell, Kassiou, Krieger, Krieger, Laurini, Liu, Liu, Liu, Liu, Mavlyutov, Monnet, Monnet, Nguyen, Nicholas Novotny, Quirion, Sarel F. Malan, Smith, Su, van Waarde, Venselaar, Werner J. Geldenhuys   +31 more
core   +1 more source

Sigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury

Scientific Reports, 2023
Sigma-1 Receptor has been shown to localize to sites of peripheral nerve injury and back pain. Radioligand probes have been developed to localize Sigma-1 Receptor and thus image pain source.
Ethan Schonfeld, Thomas Michael Johnstone, Ghani Haider, Aaryan Shah, Neelan Joseph Marianayagam, Sandip Biswal, Anand Veeravagu   +6 more
doaj   +1 more source

A Structure- and Ligand-Based Virtual Screening of a Database of “Small” Marine Natural Products for the Identification of “Blue” Sigma-2 Receptor Ligands

Marine Drugs, 2018
Sigma receptors are a fascinating receptor protein class whose ligands are actually under clinical evaluation for the modulation of opioid analgesia and their use as positron emission tomography radiotracers.
Giuseppe Floresta, Emanuele Amata, Carla Barbaraci, Davide Gentile, Rita Turnaturi, Agostino Marrazzo, Antonio Rescifina   +6 more
doaj   +1 more source

Is the sigma-1 receptor a potential pharmacological target for cardiac pathologies? A systematic review

International Journal of Cardiology: Heart & Vasculature, 2020
Sigma-1 receptors are ligand-regulated chaperone proteins, involved in several cellular mechanisms. The aim of this systematic review was to examine the effects that the sigma-1 receptor has on the cardiovascular system.
Rebecca Lewis, Jiaqi Li, Peter J McCormick, Christopher L-H Huang, Kamalan Jeevaratnam   +4 more
doaj   +1 more source

Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer [PDF]

, 2017
Background Despite considerable efforts by scientific research, pancreatic cancer is the fourth leading cause of cancer related mortalities.
Abate, Carmen, Berardi, Francesco, Hawkins, William, Hornick, John R, Niso, Mauro, Pati, Maria Laura, Spitzer, Dirk   +6 more
core   +2 more sources

Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel

Frontiers in Pharmacology, 2017
The sigma-1 receptor is a 223 amino acids molecular chaperone with a single transmembrane domain. It is resident to eukaryotic mitochondrial-associated endoplasmic reticulum and plasma membranes.
Kang Zhang, Zhe Zhao, Liting Lan, Xiaoli Wei, Liyun Wang, Xiaoyan Liu, Haitao Yan, Jianquan Zheng   +7 more
doaj   +1 more source

Anisamide-targeted gold nanoparticles for siRNA delivery in prostate cancer - synthesis, physicochemical characterisation and in vitro evaluation [PDF]

, 2018
Metastatic prostate cancer is a leading cause of cancer-related death in men and current chemotherapies are largely inadequate in terms of efficacy and toxicity. Hence improved treatments are required.
Fitzgerald, Kathleen A., Guo, Jianfeng, Holmes, Justin D., O'Driscoll, Caitríona M., Rahme, Kamil   +4 more
core   +1 more source

Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine [PDF]

, 2015
Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior.
Aguinaga, David, Cai, Ning-Sheng, Canela, Enric I, Casadó, Vicent, Cortés, Antonio, Ferré, Sergi, Hausch, Felix, Howell, Lesley A., Lluís, Carme, Mallol, Josefa, McCormick, Peter J., McDowell, Kimberly, Moreno, Estefanía, Moreno-Delgado, David, Navarro, Gemma, Quiroz, César, Rea, William, Sierakowiak, Adam   +17 more
core   +1 more source