Results 11 to 20 of about 820,649 (291)
Sigma-1 Receptors in Depression: Mechanism and Therapeutic Development
Frontiers in Pharmacology, 2022 Depression is the most common type of neuropsychiatric illness and has increasingly become a major cause of disability. Unfortunately, the recent global pandemic of COVID-19 has dramatically increased the incidence of depression and has significantly ...
Peng Ren +7 more
doaj +3 more sources
Role of sigma-1 receptors in neurodegenerative diseases
Journal of Pharmacological Sciences, 2015 Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes appear to share common mechanisms of neuronal cellular dysfunction, including excitotoxicity, calcium dysregulation, oxidative damage, ER stress and mitochondrial ...
Linda Nguyen +6 more
doaj +3 more sources
Advancing depression treatment: the role of sigma receptor ligands [PDF]
Frontiers in NeuroscienceDepression, one of the most prevalent neuropsychiatric disorders, continues to pose escalating global health challenges. Despite the discovery of numerous antidepressants, their clinical applications are limited, and there is still an urgent need to ...
Peng Zhang +6 more
doaj +2 more sources
A Role for Sigma Receptors in Stimulant Self Administration and Addiction [PDF]
Pharmaceuticals, 2011 Sigma1 receptors (σ1Rs) represent a structurally unique class of intracellular proteins that function as chaperones. σ1Rs translocate from the mitochondria-associated membrane to the cell nucleus or cell membrane, and through protein-protein interactions
Shang-Yi Tsai +6 more
doaj +2 more sources
Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins
Pharmaceuticals, 2023 Itch and pain are closely related but distinct sensations that share largely overlapping mediators and receptors. We hypothesized that the novel, multi-target compound E153 has the potential to attenuate pain and pruritus of different origins.
Szczepan Mogilski +7 more
doaj +1 more source
Sigma Receptor Binding Assays [PDF]
Current Protocols in Pharmacology, 2015 AbstractSigma receptors, both Sigma‐1(S1R) and Sigma‐2 (S2R), are small molecule‐regulated, primarily endoplasmic reticulum (ER) membrane‐associated sites. A number of drugs bind to sigma receptors, including the antipsychotic haloperidol and (+)‐pentazocine, an opioid analgesic.
Uyen B, Chu, Arnold E, Ruoho
openaire +2 more sources
Frontiers in Pharmacology, 2020 Sigma-1 and sigma-2 receptors are emerging therapeutic targets. Although the molecular identity of the sigma-2 receptor has recently been determined, receptor quantitation has used, and continues to use, the sigma-1 selective agents (+) pentazocine or ...
Haider Abbas +5 more
doaj +1 more source
Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells
Pathogens, 2021 (1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern.
David A. Ostrov +15 more
doaj +1 more source
The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception [PDF]
Molecular Brain, 2020 Abstract The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also facilitates the development of neuropathic pain. Based on these findings, the recent cloning of the Sigma-2 receptor (σ2R) led us to investigate its potential role as a regulator ...
Pilar Sánchez-Blázquez +4 more
openaire +4 more sources
Sigma receptors as potential therapeutic targets for neuroprotection. [PDF]
Eur J Pharmacol, 2014 Nguyen L +3 more
europepmc +2 more sources