Results 31 to 40 of about 820,649 (291)
Combination of Heme Oxygenase-1 Inhibition and Sigma Receptor Modulation for Anticancer Activity
Molecules, 2021 Cancer is a multifactorial disease that may be tackled by targeting different signaling pathways. Heme oxygenase-1 (HO-1) and sigma receptors (σRs) are both overexpressed in different human cancers, including prostate and brain, contributing to the ...
Giuseppe Romeo +11 more
doaj +1 more source
STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]
, 2018 Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F +7 more
core +2 more sources
Marine Drugs, 2018 Sigma receptors are a fascinating receptor protein class whose ligands are actually under clinical evaluation for the modulation of opioid analgesia and their use as positron emission tomography radiotracers.
Giuseppe Floresta +6 more
doaj +1 more source
Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors [PDF]
, 2014 Mammals express the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). Neu5Gc is synthesized from Neu5Ac by the enzyme
Böhm, Raphael +14 more
core +1 more source
The Role of Sigma Receptors in Depression
Journal of Pharmacological Sciences, 2005 Behavioral models used to test potential antidepressants have shown that ligands that bind to sigma receptors possess “antidepressant-like” properties.
Jordanna E. Bermack, Guy Debonnel
doaj +1 more source
Cardiac Sigma Receptors – An Update
Physiological Research, 2018 More than four decades passed since sigma receptors were first mentioned. Since then, existence of at least two receptor subtypes and their tissue distributions have been proposed. Nowadays, it is clear, that sigma receptors are unique ubiquitous proteins with pluripotent function, which can interact with so many different classes of proteins.
T, Stracina, M, Novakova
openaire +2 more sources
Pregnancy reduces brain sigma receptor function [PDF]
British Journal of Pharmacology, 1999 Sigma (σ) receptors have recently been cloned, though their endogenous ligand(s) remain unidentified. However, some neuroactive steroids, such as progesterone, have a high affinity for these receptors. Some σ ligands, such as DTG, (+)‐pentazocine and DHEA, act as σ ‘agonists’ by potentiating the neuronal response to NMDA. Others, such as haloperidol,
R, Bergeron, C, de Montigny, G, Debonnel
openaire +2 more sources
Extracellular aspartic protease SAP2 of Candida albicans yeast cleaves human kininogens and releases proinflammatory peptides, Met-Lys-bradykinin and des-Arg(9)-Met-Lys-bradykinin [PDF]
, 2012 Bradykinin-related peptides, universal mediators of inflammation collectively referred to as the kinins, are often produced in excessive amounts during microbial infections.
Alexander Faussner +16 more
core +1 more source
Frontiers in Pharmacology, 2020 These unprecedented times have forced the scientific community to gather to face the COVID-19 pandemic. Efforts in diverse directions have been made. A multi-university team has focused on the identification of the host (human) proteins interacting with ...
Carmen Abate +5 more
doaj +1 more source
Adamantane-derived scaffolds targeting the sigma-2 receptor; an in vitro and in silico study
Saudi Pharmaceutical Journal, 2021 Novel adamantane-based compounds were synthesized and assessed as potential sigma-2 receptor ligands. Molecular docking and 50 ns molecular dynamic simulation were carried out to determine the binding modes, mechanism of interaction, and stability of ...
Mohammed A. Alamri, Mubarak A. Alamri
doaj +1 more source