Results 101 to 110 of about 1,192,373 (315)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Scientific Reports, 2017 Large molecular complexes known as inflammasomes regulate the release of IL-1β from immune cells in response to infection and injury. Salmonella typhimurium infection is reported to activate NLRP3 and NLRC4 inflammasomes which are subsequently involved ...
Catherine E. Diamond +5 more
doaj +1 more source
, 2021 Signs are the basis of all communication. Semiotics—the study of signs—has increasingly become an area of intellectual inquiry, and the word itself is now even known to the general public, thanks to the popularity ofnovels by David Lodge and the fame of Umberto Eco. No one has done more to advance the study of signs than Thomas A. Sebeok.
openaire +2 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Phagocytosis of particulate antigens - all roads lead to calcineurin/NFAT signaling pathway
Frontiers in Immunology, 2014 Jan eFric +2 more
doaj +1 more source
Harlem Globetrotters road sign
, 1965 Scenic 89 tourism road sign photographed along Highway 89 in Davis County as part of a project by the State Department of Highways to document Utah highways signs.4 inches x 5 inchesThis series contains outdoor advertising sign inventories conducted by ...
Road Commission. Department of Highways
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
, 1965 Scenic 89 tourism road sign photographed along Highway 89 in Garfield County as part of a project by the State Department of Highways to document Utah highways signs.4 inches x 5 inchesThis series contains outdoor advertising sign inventories conducted ...
Road Commission. Department of Highways
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
SLAMF7 defines subsets of human effector CD8 T cells
Scientific ReportsLong-term control of viral replication relies on the efficient differentiation of memory T cells into effector T cells during secondary immune responses.
Hassen Kared +11 more
doaj +1 more source