Results 121 to 130 of about 1,192,373 (315)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

A ministry of (not-so-silly) walks: Investigating classifier handshapes for animate referents in DGS

open access: yesOpen Linguistics
Across sign languages, classifier predicates depict the movement, location, or manipulation of (in-)animate entities. Each classifier predicate contains a classifier handshape that represents a referent based on one or more of its salient semantic and/or
Lettow Isabeau, Loos Cornelia
doaj   +1 more source

Utahhybrid Corn Seed road sign

open access: yes, 1965
Utahybrid Corn Seed road sign photographed along Highway 89 in Davis County as part of a project by the State Department of Highways to document Utah highway signs.This series contains outdoor advertising sign inventories conducted by the Department of ...
Road Commission. Department of Highways
core  

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Jacobs Lake Inn road sign

open access: yes, 1965
Scenic 89 tourism road sign photographed along Highway 89 in Kane County as part of a project by the State Department of Highways to document Utah highways signs.4 inches x 5 inchesThis series contains outdoor advertising sign inventories conducted by ...
Road Commission. Department of Highways
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

The Drifter Restaurant road sign

open access: yes, 1967
Scenic 89 tourism road sign photographed along Highway 89 in Kane County as part of a project by the State Department of Highways to document Utah highways signs.4 inches x 5 inchesThis series contains outdoor advertising sign inventories conducted by ...
Road Commission. Department of Highways
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

The immune milieu after local endometrial injury in women with recurrent implantation failure

open access: yesScientific Reports
Recurrent implantation failure (RIF) occurs in 10–15% of IVF cycles with evidence from a few randomized control trials (RCTs) that local endometrial injury (LEI) leads to higher live birth rates whose exact mechanism is currently unknown.
Yiping Fan   +7 more
doaj   +1 more source

Welcome to Panguitch road sign

open access: yes, 1965
Scenic 89 tourism road sign photographed along Highway 89 in Garfield County as part of a project by the State Department of Highways to document Utah highways signs.4 inches x 5 inchesThis series contains outdoor advertising sign inventories conducted ...
Road Commission. Department of Highways
core  

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