Results 21 to 30 of about 4,685,588 (297)

Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury

open access: yesNature Communications, 2019
Severe malaria can be associated with respiratory complications. Here, the authors show that malaria-associated pulmonary vascular damage is a consequence of IFNγ-activated lung endothelial cells capturing, processing, and cross-presenting malaria ...
Carla Claser   +13 more
doaj   +1 more source

CD103+ Dendritic Cells Control Th17 Cell Function in the Lung

open access: yesCell Reports, 2015
Th17 cells express diverse functional programs while retaining their Th17 identity, in some cases exhibiting a stem-cell-like phenotype. Whereas the importance of Th17 cell regulation in autoimmune and infectious diseases is firmly established, the ...
Teresa Zelante   +14 more
doaj   +1 more source

Numeral Incorporation as Grammaticalization? A Corpus Study on German Sign Language (DGS)

open access: yesLanguages, 2023
Numeral incorporation describes the merging of a numeral sign with a lexical sign to create a single sign with a compositional meaning, e.g., “three weeks.” As a phenomenon of simultaneous morphology, numeral incorporation is unique to sign languages ...
Felicitas Otte   +3 more
doaj   +1 more source

Mutating chikungunya virus non‐structural protein produces potent live‐attenuated vaccine candidate

open access: yesEMBO Molecular Medicine, 2019
Currently, there are no commercially available live‐attenuated vaccines against chikungunya virus (CHIKV). Here, CHIKVs with mutations in non‐structural proteins (nsPs) were investigated for their suitability as attenuated CHIKV vaccines.
Yi‐Hao Chan   +15 more
doaj   +1 more source

A Novel, Five-Marker Alternative to CD16–CD14 Gating to Identify the Three Human Monocyte Subsets

open access: yesFrontiers in Immunology, 2019
Human primary monocytes are heterogeneous in terms of phenotype and function, but are sub-divided only based on CD16 and CD14 expression. CD16 expression distinguishes a subset of monocytes with highly pro-inflammatory properties from non-CD16 expressing
Siew-Min Ong   +12 more
doaj   +1 more source

RULES FOR ESTONIAN SIGN LANGUAGE TRANSCRIPTION; pp. 401–424 [PDF]

open access: yesTrames, 2009
Estonian Sign Language (ESL) is the native language for approximately 1,500 Estonian dDeaf people. Like other sign languages, ESL has no written form. In the history of ESL research, different transcription systems have been used.
Regina Paabo   +2 more
doaj   +1 more source

Reduction of the sign problem using the meron-cluster approach

open access: yes, 2003
The sign problem in quantum Monte Carlo calculations is analyzed using the meron-cluster solution. The concept of merons can be used to solve the sign problem for a limited class of models.
A.W. Sandvik   +12 more
core   +1 more source

Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus‐specific neutralizing antibody response

open access: yesEMBO Molecular Medicine, 2014
RNA‐sensing toll‐like receptors (TLRs) mediate innate immunity and regulate anti‐viral response. We show here that TLR3 regulates host immunity and the loss of TLR3 aggravates pathology in Chikungunya virus (CHIKV) infection.
Zhisheng Her   +19 more
doaj   +1 more source

NLRP10 Enhances CD4+ T-Cell-Mediated IFNγ Response via Regulation of Dendritic Cell-Derived IL-12 Release

open access: yesFrontiers in Immunology, 2017
NLRP10 is a nucleotide-binding oligomerization domain-like receptor that functions as an intracellular pattern recognition receptor for microbial products.
Maurizio Vacca   +21 more
doaj   +1 more source

Endoplasmic reticulum stress response and bile acid signatures associate with multi-strain seroresponsiveness during elderly influenza vaccination

open access: yesiScience, 2021
Summary: The elderly are an important target for influenza vaccination, and the determination of factors that underlie immune responsiveness is clinically valuable.
Christophe Carre   +17 more
doaj   +1 more source

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