Results 81 to 90 of about 4,685,588 (297)
Dynkin's Isomorphism with Sign Structure [PDF]
, 2007 The Dynkin isomorphism associates a Gaussian field to a Markov chain. These Gaussian fields can be used as priors for prediction and time series analysis. Dynkin's construction gives Gaussian fields with all non-negative covariances.
Khare, Kshitij
core
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Nature Communications, 2016 The tools for constructing cell lineages from single cell data are limited. Here, the authors present Mpath: an algorithm to derive multi-branching trajectories using neighbourhood-based cell state transitions, and use this to predict developmental ...
Jinmiao Chen +4 more
doaj +1 more source
A new framework for sign language recognition based on 3D handshape identification and linguistic modeling [PDF]
, 2014 Current approaches to sign recognition by computer generally have at least some of the following limitations: they rely on laboratory conditions for sign production, are limited to a small vocabulary, rely on 2D modeling (and therefore cannot deal with ...
Dilsizian, Mark +4 more
core
Inference for VARs Identified with Sign Restrictions
, 2018 There is a fast growing literature that set-identifies structural vector autoregressions (SVARs) by imposing sign restrictions on the responses of a subset of the endogenous variables to a particular structural shock (sign-restricted SVARs). Most methods
Granziera, Eleonora +2 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Asymptotic sign coherence conjecture [PDF]
, 1971 The sign coherence phenomenon is an important feature of c-vectors in cluster algebras with principal coefficients. In this note, we consider a more general version of c-vectors defined for arbitrary cluster algebras of geometric type and formulate a ...
Gekhtman, Michael, Nakanishi, Tomoki
core +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Ergonomic assessment of kitchen workspace demands among older adults in India
Discover Public HealthIndian kitchens remain physically demanding environments for older adults, who routinely perform labour-intensive tasks such as kneading, chopping, grinding, stirring, and utensil washing.
Soumya Kanti Deb, S. Saleem Ahmed
doaj +1 more source