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Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitisopenaire
Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic miceopenaire
Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis
Biological and Pharmaceutical Bulletin, 2021 Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein involved in inflammatory and immune responses, such as inflammatory bowel disease and allergic responses. In this study, we investigated the role of STAP-2 in the pathogenesis of autoimmune hepatitis.
Yuto Sasaki +2 more
exaly +5 more sources
Biochemical and Biophysical Research Communications, 2021 Signal-transducing adaptor protein (STAP)-2 is one of the STAP family adaptor proteins and ubiquitously expressed in a variety types of cells. Although STAP-2 is required for modification of FcεRI signal transduction in mast cells, other involvement of STAP-2 in mast cell functions is unknown, yet.
Jun-Ichi Kashiwakura +2 more
exaly +4 more sources
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European Journal of Immunology, 2014
Signal‐transducing adaptor protein‐2 (STAP‐2) was cloned as a c‐fms/M‐CSF receptor interacting protein. STAP‐2 is an adaptor protein carrying pleckstrin homology and Src homology 2 like domains, as well as a YXXQ motif. STAP‐2 has been indicated to have an ability to bind and modulate a variety of signaling and transcriptional molecules.
Natsuko Fujita +2 more
exaly +3 more sources
Signal‐transducing adaptor protein‐2 (STAP‐2) was cloned as a c‐fms/M‐CSF receptor interacting protein. STAP‐2 is an adaptor protein carrying pleckstrin homology and Src homology 2 like domains, as well as a YXXQ motif. STAP‐2 has been indicated to have an ability to bind and modulate a variety of signaling and transcriptional molecules.
Natsuko Fujita +2 more
exaly +3 more sources
Hrs, a Mammalian Master Molecule in Vesicular Transport and Protein Sorting, Suppresses the Degradation of ESCRT Proteins Signal Transducing Adaptor Molecule 1 and 2 [PDF]
Journal of Biological Chemistry, 2005 The degradation and sorting of cytoplasmic and cell-surface proteins are crucial steps in the control of cellular functions. We previously identified three mammalian Vps (vacuolar protein sorting) proteins, Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) and signal transducing adaptor molecule (STAM) 1 and -2, which are tyrosine ...
Nobuyuki Tanaka +2 more
exaly +3 more sources
Biological and Pharmaceutical Bulletin, 2008 Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein as a c-Fms/M-CSF receptor-interacting protein and constitutively expressed in macrophages. In our previous study, we examined the role of STAP-2 in the c-Fms/M-CSF receptor signaling using a murine macrophage tumor cells line, Raw264.7.
Yuichi Sekine +2 more
exaly +5 more sources
Biochemical and Biophysical Research Communications, 2021
Graft-versus-host disease (GVHD) is the most frequent complication after allogeneic hematopoietic stem cell transplantation (HSCT), and is one of the major causes of non-relapse mortality. Transferred mature lymphocytes are thought to be responsible for GVHD based on the findings that mice transplanted with lymphocyte-depleted bone marrow (BM) cells ...
Hideaki Saito +2 more
exaly +3 more sources
Graft-versus-host disease (GVHD) is the most frequent complication after allogeneic hematopoietic stem cell transplantation (HSCT), and is one of the major causes of non-relapse mortality. Transferred mature lymphocytes are thought to be responsible for GVHD based on the findings that mice transplanted with lymphocyte-depleted bone marrow (BM) cells ...
Hideaki Saito +2 more
exaly +3 more sources
Signal-transducing adaptor protein-2 modulates T-cell functions
Exploration of ImmunologyImmune responses are orchestrated by controlling the initiation, magnitude, and duration of various signaling pathways. Adaptor proteins act as positive or negative regulators by targeting critical molecules of signaling cascades. Signal-transducing adaptor protein-2 (STAP-2) contains typical features of adaptor proteins, like a pleckstrin homology (PH)
Tadashi Matsuda +2 more
exaly +1 more source
ESCRT-0 Protein Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (Hrs) Is Targeted to Endosomes Independently of Signal-transducing Adaptor Molecule (STAM) and the Complex Formation with STAM Promotes Its Endosomal Dissociation [PDF]
Journal of Biological Chemistry, 2014 The ESCRT-0 complex, consisting of the hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) and the signal-transducing adaptor molecule (STAM) proteins, recognizes ubiquitylated cargo during the initial step of endosomal sorting. The endosomal accumulation of overexpressed Hrs has been reported previously to be associated with endosome ...
Katsuhiko Kojima +2 more
exaly +4 more sources