Results 51 to 60 of about 61,509 (283)

TCR triggering induces the formation of Lck-RACK1-actinin-1 multiprotein network affecting Lck redistribution

Frontiers in Immunology, 2016
The initiation of T-cell signaling is critically dependent on the function of the member of Src family tyrosine kinases (SFKs), Lck. Upon TCR triggering, Lck kinase activity induces the nucleation of signal-transducing hubs that regulate the formation of
Ondrej Ballek, Jan Valečka, Martina Dobešová, Adéla Broučková, Jasper Manning, Pavel Řehulka, Jiří Stulík, Dominik Filipp   +7 more
doaj   +1 more source

Ubiquitin: Same Molecule, Different Degradation Pathways [PDF]

, 2010
Ubiquitin is a common demoninator in the targeting of substrates to all three major protein degradation pathways in mammalian cells: the proteasome, the lysosome, and the autophagosome.
Clague, Michael J., Urbé, Sylvie
core   +1 more source

Future therapeutic strategies: Implications for Brk targeting [PDF]

, 2011
The official published article can be found at the link below - Copyright @ 2011 InTech. This Article has been provided by the Brunel Open Access Publishing Fund.Rajpal Burmi was supported by a Breast Cancer Campaign project ...
Burmi, RS, Harvey, AJ
core   +2 more sources

A Mendelian randomized study on the correlation between 91 inflammatory protein levels and the risk of acute myeloid leukemia [PDF]

Zhenduanxue lilun yu shijian
Objective The study aims to analyze the correlation between circulating inflammatory proteins and the risk of acute myeloid leukemia (AML). Methods AML data were obtained from the FinnGen alliance as the outcome. The Genome-wide Association Studies (GWAS)
AN Huihui, WU Tao, LIU Wenhui, TIAN Sirui
doaj   +1 more source

EGF receptor trafficking: consequences for signaling and cancer [PDF]

, 2013
The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of that traffic in signal transduction.
Eden, ER, Futter, CE, Tomas, A
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Nonsynonymous substitution rate (Ka) is a relatively consistent parameter for defining fast-evolving and slow-evolving protein-coding genes

Biology Direct, 2011
Background Mammalian genome sequence data are being acquired in large quantities and at enormous speeds. We now have a tremendous opportunity to better understand which genes are the most variable or conserved, and what their particular functions and ...
Wang Lei, Liu Fei, Wang Dapeng, Huang Shi, Yu Jun   +4 more
doaj   +1 more source

Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1- And Rab8-Dependent and recycling endosome-independent [PDF]

, 2014
The intermediate conductance, Ca2+-activated K+ channel (KCa3.1) targets to the basolateral (BL) membrane in polarized epithelia where it plays a key role in transepithelial ion transport.
A Al-Hazza, A Duffield, A Schwab, A Wulf, AC Gerlach, Agustin Guerrero-Hernandez, AH Hutagalung, AL Ang, AL Ang, C Barmeyer, C Dong, C Dong, C Gorbea, CA Syme, CE Futter, CE Futter, Claudia A. Bertuccio, CM Babbey, CM Balut, CM Balut, CM Balut, CM Filipeanu, Daniel C. Devor, DC Devor, DC Devor, DC Devor, DC Devor, DC Devor, E Orzech, EJ Tisdale, FE Reyes-Turcu, G Griffiths, G Wu, GA Farr, Guangyu Wu, H Fölsch, H Ohno, HM Jones, HM Jones, I Pilecka, J Cancino, JL Seachrist, JS Yoo, Kirk L. Hamilton, LA Simms, M Albaqumi, M Jeffers, Michael B. Butterworth, MM Hammad, O Martinez, O Staub, P van Kerkhof, PA Rufo, R Warth, S Singh, SD Fuller, Shih-Liang Lee, SM Millard, SX Lin, TM Ishii, TR Muth, WJ Joiner, WJ Joiner, WJ Joiner, X Zhang, X Zhuang, Y Gao, Y Gao, Z Galcheva-Gargova   +68 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source