Results 91 to 100 of about 5,505,088 (293)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cryogenic and conventional milling of AZ91 magnesium alloy

Journal of Magnesium and Alloys
Use of magnesium is the need of the hour due to its low density as well as its high strength-to-weight and stiffness-to-weight ratio etc. This study focuses on the effectiveness of liquid nitrogen (LN2) assisted cryogenic machining on the surface ...
Vikas Marakini, Srinivasa Pai P, Gururaj Bolar, Bhaskara P Achar   +3 more
doaj   +1 more source

Si ₃ N ₄ :HfO ₂ dual‐k spacer bulk planar junctionless transistor for mixed signal integrated circuits

IET Circuits, Devices & Systems, 2018
For the first time halfnium oxide (HfO 2 ) is being incorporated in the dual‐k spacers and has been used in bulk planar junctionless transistor (BPJLT). It has been found that incorporating HfO 2 in spacers not only improves the electrostatic integrity ...
Ramarao Garike, Ganesh C. Patil
openaire   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Safeguarding integrity: a guide to the integrity system in Victoria [PDF]

, 2014
The Safeguarding Integrity Guide aims to help public sector employees and the broader community understand Victoria\u27s integrity system and its key agencies.

core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

SSTA-SI: Signal Integrity Effects Aware Statistical Static Timing Analysis

, 2007
We study signal integrity effects on statistical timing analysis, e.g., interconnect and gate delay variations induced by crosstalk aggressor alignment, i.e., difference in signal arrival times in coupled neighboring interconnects. Such effects bring significant source of variation, and must be taken into account in statistical timing analysis.
Liu, Bao, Xu, Xu, Kahng, Andrew
openaire   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source