Results 71 to 80 of about 5,505,088 (293)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A 32 Gb/s 0.41 pJ/bit Single-Ended Transmitter with TX-Based-Only Adaptive Crosstalk Cancellation for Ultra-Short-Reach Wireline Applications

Applied Sciences
Driven by the rapid advancement of artificial intelligence (AI) workloads, the demand for high-bandwidth and energy-efficient die-to-die (D2D) wireline communication has significantly increased. The article presents an original lumped-parameter model for
Yixuan Shen, Zexin Su, Chang Liu, Xiao Ma, Lei Wang, Bo Li   +5 more
doaj   +1 more source

Design and metrological validation of a programmable high-voltage I–V measurement system for dielectric breakdown kinetics [PDF]

Quy Nhon University Journal of Science
Accurately distinguishing between intrinsic dielectric breakdown and instrument-induced compliance artifacts is a fundamental requirement in semiconductor reliability metrology. To address this requirement, this paper presents the design and metrological
Huynh Cong Tu, Nguyen Van Hao
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A Machine Learning-Based Epistemic Modeling Framework for EMC and SI Assessment [PDF]

, 2020
A novel machine learning-based framework is presented to evaluate the effect of design parameters, affected by epistemic uncertainty, on the Signal Integrity (SI) and Electromagnetic Compatibility (EMC) performance of electronic products.
Dhaene T., Kan D., Spina D., Rogier H., Grassi F., Ginste D. V., De Ridder S.   +6 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Study of signal integrity and synopsys primetime SI

, 2015
One of the most imp01tant advances in deep sub-micron level design is in the area of signal integrity. Signal integrity issues are not only preventing flawless operation at high speed level design, but also in some cases causing physical damage to the ...
Deshpande, Nikhil
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source