Results 111 to 120 of about 7,822,395 (293)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Signal Processing for Computer Vision

, 1995
Signal Processing for Computer Vision is a unique and thorough treatment of the signal processing aspects of filters and operators for low-level computer vision. Computer vision has progressed considerably over recent years.
Knutsson, Hans, Granlund, Gösta H.
core   +2 more sources

Decision making process for clinical it investments in a public health care organization – contingency approach to support the investment decision process

Finnish Journal of eHealth and eWelfare, 2015
Purpose Health care organizations are lacking a clear decision-making framework in IT investment decisions. This study aims at finding a practical tool able to take the different financial and non-financial factors into account.
Johanna Lamminen, Heikki Forsvik, Ville Voipio, Lasse Lehtonen   +3 more
doaj  

Advances in non-invasive EEG-based brain-computer interfaces: Signal acquisition, processing, emerging approaches, and applications

Brain-computer interfaces (BCIs) have revolutionized the field of human-computer interaction, enabling direct communication between the human brain and external devices.
Kumar, S, Sharma, A
core   +1 more source

Implementation of a Human-Computer Interface for Computer Assisted Translation and Handwritten Text Recognition [PDF]

, 2012
A human-computer interface is developed to provide services of computer assisted machine translation (CAT) and computer assisted transcription of handwritten text images (CATTI). The back-end machine translation (MT) and handwritten text recognition (HTR)
Ocampo Sepúlveda, Jorge Carlos
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Publication productivity of Malaysian researchers in the field of Computer Science and Information Technology [PDF]

, 2001
Searches made in the CD-ROM databases, COMPENDEX (1987-1999), IEL (IEE/IEEE Electronic Library) (1988-1999) and INSPEC (1990-1998) revealed a total of 389 publications contributed by Malaysian researchers in the field of computer science and information ...
Zainab, A.N., Zainab, AN, Gu, Y.
core   +2 more sources

Statistical signal processing for automotive safety systems

, 2005
The amount of software in general and safety systems in particular increases rapidly in the automotive industry. The trend is that functionality is decentralized, so new safety functions are distributed to common shared computer hardware, sensors and ...
F. Gustafsson, Gustafsson, Fredrik,
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source