Results 241 to 250 of about 258,387 (282)

The signal recognition particle of Archaea

Trends in Microbiology, 2001
It is becoming increasingly clear that similarities exist in the manner in which extracytoplasmic proteins are targeted to complexes responsible for translocating these proteins across membranes in each of the three domains of life. In Eukarya and Bacteria, the signal recognition particle (SRP) directs nascent polypeptides to membrane-embedded ...
J, Eichler, R, Moll
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Biogenesis of the signal recognition particle

Biochemical Society Transactions, 2010
Assembly of ribonucleoprotein complexes is a facilitated quality-controlled process that typically includes modification to the RNA component from precursor to mature form. The SRP (signal recognition particle) is a cytosolic ribonucleoprotein that catalyses protein targeting to the endoplasmic reticulum.
Leung E, Brown JD
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Structural basis of signal-sequence recognition by the signal recognition particle

Nature Structural & Molecular Biology, 2011
The signal recognition particle (SRP) recognizes and binds the signal sequence of nascent proteins as they emerge from the ribosome. We present here the 3.0-Å structure of a signal sequence bound to the Methanococcus jannaschii SRP core. Structural comparison with the free SRP core shows that signal-sequence binding induces formation of the GM-linker ...
Tobias, Hainzl, Shenghua, Huang, Gitte, Meriläinen, Kristoffer, Brännström, A Elisabeth, Sauer-Eriksson   +4 more
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Structural Insights Into the Signal Recognition Particle

Annual Review of Biochemistry, 2004
▪ Abstract  The signal recognition particle (SRP) directs integral membrane and secretory proteins to the cellular protein translocation machinery during translation. The SRP is an evolutionarily conserved RNA-protein complex whose activities are regulated by GTP hydrolysis.
Jennifer A, Doudna, Robert T, Batey
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Protein targeting by the signal recognition particle

bchm, 2009
Abstract Protein targeting by the signal recognition particle (SRP) is universally conserved and starts with the recognition of a signal sequence in the context of a translating ribosome. SRP54 and FtsY, two multidomain proteins with guanosine triphosphatase (GTPase) activity, are the central elements of the SRP system.
Przemyslaw, Grudnik, Gert, Bange, Irmgard, Sinning   +2 more
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Signal recognition particle (SRP)

1994
Abstract The particle is comprised of one molecule of 7SL RNA (about 300 nucleotides) and six distinct polypeptides3 The six SRP polypeptide chains are organized into four SRP proteins. These are two monomers, a 19 kDa polypeptide and a 54 kDa polypeptide, and two heterodimers, one composed of a 9 kDa and a 14 kDa polypeptide (p9/14 ...
D L Zimmerman, P Walter
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The signal recognition particle in S. cerevisiae

Trends in Cell Biology, 1991
We have identified the Saccharomyces cerevisiae homolog of the signal recognition particle (SRP) and characterized its function in vivo. S. cerevisiae SRP is a 16S particle that includes a homolog of the signal sequence-binding protein subunit of SRP (SRP54p) and a small cytoplasmic RNA (scR1).
B C, Hann, P, Walter
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Disassembly and reconstitution of signal recognition particle

Cell, 1983
Signal recognition particle (SRP) is a ribonucleoprotein consisting of six distinct polypeptides and one molecule of small cytoplasmic 7SL-RNA. The particle was previously shown to function in protein translocation across, and protein integration into, the endoplasmic reticulum membrane.
P, Walter, G, Blobel
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Functional dissection of the signal recognition particle

Trends in Biochemical Sciences, 1988
Abstract Biochemical mutagenesis — alteration or removal of specific domains within a biological structure — followed by functional analysis, gives insight into structure-function relationships. We describe the analysis of the signal recognition particle, a ribonucleoprotein known to be required for the entry of most proteins into the secretory ...
V, Siegel, P, Walter
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New Insights into Signal Recognition and Elongation Arrest Activities of the Signal Recognition Particle

Biological Chemistry, 1999
AbstractThe signal recognition particle (SRP), a ubiquitous cytoplasmic ribonucleoprotein particle, plays an essential role in promoting co-translational translocation of proteins into the endoplasmic reticulum. Here, we summarise recent progress made in the understanding of two essential SRP functions: the signal recognition function, which ensures ...
Bui, Nazarena, Strub, Katharina
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