Results 111 to 120 of about 146,182 (290)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Proteomic profile of KSR1-regulated signalling in response to genotoxic agents in breast cancer [PDF]

, 2015
Kinase suppressor of Ras 1 (KSR1) has been implicated in tumorigenesis in multiple cancers, including skin, pancreatic and lung carcinomas. However, our recent study revealed a role of KSR1 as a tumour suppressor in breast cancer, the expression of which
A Franceschini, AA Adjei, Arnhild Grothey, B Gyorffy, Cancer Genome Atlas Network, F Yan, F Yan, Georgios Giamas, H Xing, H Zhang, H Zhang, H Zhang, HR Xing, Hua Zhang, I Youlyouz-Marfak, J Cox, J Cox, J Lozano, J Stebbing, J Wielemaker, J Xu, J Zhang, Joao Nunes, Justin Stebbing, JV Olsen, K Kornfeld, L Hannesdottir, M Alcoceba, M Ashburner, M Kim, M Sundaram, M Therrien, M Therrien, Nicos Angelopoulos, NR Michaud, O Tacar, P Tymoszuk, PJ Klutho, R Kaneno, S Datta, S Falcon, S Zhu, Y Cao, Y Pommier, Y Xu, Y Zhang, Y Zhang, Yichen Xu, YJ Jeon   +48 more
core   +3 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Epithelial cell–derived secreted and transmembrane 1a signals to activated neutrophils during pneumococcal pneumonia [PDF]

, 2016
Airway epithelial cell responses are critical to the outcome of lung infection. In this study, we aimed to identify unique contributions of epithelial cells during lung infection.
Belkina, Anna C., Deng, Jane C., Gower, Adam C., Jones, Matthew R., Kamata, Hirofumi, Lung, Wing Yi, Mizgerd, Joseph P., Quinton, Lee J., Ramirez, Maria I., Wasserman, Gregory A., Yamamoto, Kazuko, Yuen, Constance K., Zabinski, Mary C.   +12 more
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Role of Janus kinase 1 and signal transducer and activator of transcription 3 in vitiligo

Clinical, Cosmetic and Investigational Dermatology, 2019
Rehab M Samaka,1 Mohammed A Basha,2 Dina Menesy31Department of Pathology, Faculty of Medicine, Menoufia University, Shibīn al Kawm, Egypt; 2Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shibīn al Kawm, Egypt ...
Samaka RM, Basha MA, Menesy D
doaj  

Knockdown of long non-coding RNA HOXD-AS1 inhibits gastric cancer cell growth via inactivating the JAK2/STAT3 pathway

Tumor Biology, 2017
Long non-coding RNA HOXD-AS1 (HOXD cluster antisense RNA 1) has been demonstrated to be closely associated with the progression of several tumors. However, the biological function of HOXD-AS1 and the underlying molecular mechanism in gastric cancer are ...
Li Zheng, Jiangtao Chen, Zhongyong Zhou, Zhikuan He   +3 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Effect of hyperthyroidism on circulating prolactin and hypothalamic expression of tyrosine hydroxylase, prolactin signaling cascade members and estrogen and progesterone receptors during late pregnancy and lactation in the rat [PDF]

, 2017
Hyperthyroidism (HyperT) compromises pregnancy and lactation, hindering suckling-induced PRL release. We studied the effect of HyperT on hypothalamic mRNA (RT-qPCR) and protein (Western blot) expression of tyrosine hydroxylase (TH), PRL receptor (PRLR ...
Jahn, Graciela Alma, Neira, Flavia Judith, Pennacchio, Gisela Erika, Soaje, Marta, Valdez, Susana Ruth   +4 more
core   +1 more source

Signal transducer and activator of transcription 3 regulation by novel binding partners

World Journal of Biological Chemistry, 2015
Signal transducers and activators of transcription (STATs) mediate essential signals for various biological processes, including immune responses, hematopoiesis, and neurogenesis. STAT3, for example, is involved in the pathogenesis of various human diseases, including cancers, autoimmune and inflammatory disorders. STAT3 activation is therefore tightly
Matsuda, Tadashi, Muromoto, Ryuta, Sekine, Yuichi, Togi, Sumihito, Kitai, Yuichi, Kon, Shigeyuki, Oritani, Kenji   +6 more
openaire   +3 more sources