Results 221 to 230 of about 98,037 (252)

Antitumor Activity of Novel Signal Transducer and Activator of Transcription 3 Inhibitors on Retinoblastoma

Molecular Pharmacology, 2021
Signal transducer and activator of transcription 3 (STAT3) is a plausible therapeutic target in the treatment of retinoblastoma, the most common intraocular malignant tumor in children. STAT3, a transcription factor of several genes related to tumorigenesis, is activated in retinoblastoma tumors as well as other cancers.
Dong Hyun, Jo, Seungbeom, Lee, Eunoo, Bak, Chang Sik, Cho, Young Taek, Han, Kyeojin, Kim, Young-Ger, Suh, Jeong Hun, Kim   +7 more
openaire   +2 more sources

Signal transducer and activator of transcription 3 inhibitors: a patent review

Expert Opinion on Therapeutic Patents, 2010
Aberrant activation of signal transducer and activator of transcription (Stat) 3, a member of the STAT family of proteins, is prevalent in numerous human cancers and is now widely recognized as a critical molecular abnormality and a master regulator of tumor processes.
Brent D G, Page, Daniel P, Ball, Patrick T, Gunning   +2 more
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Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis

Molecular Carcinogenesis, 2007
AbstractSignal transducer and activator of transcription 3 (Stat3) is one of a family of cytoplasmic proteins that participate in normal cellular responses to cytokines and growth factors as transcription factors. Stat3 modulates various physiological functions including cell survival, cell‐cycle regulation, and angiogenesis through regulation of gene ...
Dae Joon, Kim, Keith S, Chan, Shigetoshi, Sano, John, Digiovanni   +3 more
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Signal Transducer and Activator of Transcription 3 Promotes Leukemogenesis

Blood, 2011
Abstract Abstract 1395 We have previously shown that constitutive activation of the signal transducer and activator of transcription (STAT) 3 protein is associated with worse outcome in patients with acute myeloid leukemia (AML).
Sampa Ghoshal, Michael T Brady, Omar Ustwani, Erin Tracy, Jason Den Haese, Paul K. Wallace, Heinz Baumann, Meir Wetzler   +7 more
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Constitutive activation of signal transducer and activator of transcription 3 in epithelial ovarian carcinoma

Journal of Obstetrics and Gynaecology Research, 2009
AbstractAim:  To investigate the expressions of signal transducer and activator of transcription 3 (Stat3) and tyrosine‐activated Stat3 (p‐Stat3) in epithelial ovarian carcinoma (EOC) and their relationships with clinical pathological parameters or prognosis.Methods:  Immunohistochemical methods were used to detect the expressions of Stat3 and p‐Stat3 ...
Hao, Min, Zhao, Wei-hong
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Signal transducer and activator of transcription‐3 expression and activation is dysregulated in actinic cheilitis

Journal of Cutaneous Pathology, 2006
Background:  The present study evaluates the signal transducer and activator of transcription‐3 (STAT‐3) expression and activation in actinic cheilitis (AC) and the relationship of this protein with the degree of epithelial dysplasia.Methods:  Twenty‐five cases of AC were analyzed. Normal lip mucosa was used as a control group.
Patricia R, Cury, Cristiane, Furuse, Ney S, de Araújo, Vera C, de Araújo   +3 more
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Signal transducers and activators of transcription 1 and 3 in prostate: Effect of sexual activity

Life Sciences, 2006
The signal transducers and activators of transcription (Stat) are effector molecules downstream of cytokine receptors. Ligand occupancy of these receptors results in the tyrosine phosphorylation, dimerization and nuclear translocation of the Stat family of transcription factors and by these means regulate gene expression. Prolactin receptors as members
Abraham, Soto-Cid, L Clara R, Hernández-Kelly, María Elena, Hernández, Jorge, Manzo, M Elba, González-Mejia, Rossana C, Zepeda, Arturo, Ortega   +6 more
openaire   +2 more sources

Calpain is a signal transducer and activator of transcription (STAT) 3 and STAT5 protease

Blood, 2002
Truncation of signal transducer and activator of transcription (STAT) 5 at the carboxy-terminal domain, either by genetic engineering or by proteolytic cleavage, results in generation of dominant-negative forms. A nuclear serine protease expressed in the myeloid precursor cells is known to mediate this cleavage, but other proteases responsible for this
Atsushi, Oda, Hiroshi, Wakao, Hiroyoshi, Fujita   +2 more
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A novel target for treatment of chordoma: signal transducers and activators of transcription 3

Molecular Cancer Therapeutics, 2009
Abstract A major obstacle in the effective treatment of chordoma is that there are no identifiable biomarkers capable of predicting prognosis. Recent research has indicated that signal transducers and activators of transcription (Stat3) may be an important prognostic marker in some cancers, but its role in chordoma tumors has not been
Cao, Yang, Joseph H, Schwab, Andrew J, Schoenfeld, Francis J, Hornicek, Kirkham B, Wood, G Petur, Nielsen, Edwin, Choy, Henry, Mankin, Zhenfeng, Duan   +8 more
openaire   +2 more sources

Immunodetection of the signal transducer and activator of transcription-3 in canine haemangioma and haemangiosarcoma

Research in Veterinary Science, 2006
The aim of this study was to examine the expression of signal transducer and activator of transcription 3 (STAT3) in canine haemangiomas and haemangiosarcomas. STAT3 protein was demonstrated in both the cytoplasm and nuclei of labelled cells. The expression of STAT3 was observed in 87.50% (35/40) of both haemangiomas and haemangiosarcomas and 72.22 ...
PETTERINO, CLAUDIO, ROSSETTI, ENRICA, DRIGO, MICHELE   +2 more
openaire   +3 more sources