Results 101 to 110 of about 1,137,727 (346)

Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model

Communications Biology
Whether organ-specific regeneration is induced by organ-specific endothelial cells (ECs) remains unelucidated. The formation of white matter lesions due to chronic cerebral hypoperfusion causes cognitive decline, depression, motor dysfunction, and even ...
Yuichi Matsui, Fumitaka Muramatsu, Hajime Nakamura, Yoshimi Noda, Kinnosuke Matsumoto, Haruhiko Kishima, Nobuyuki Takakura   +6 more
doaj   +1 more source

Protocol for CRISPR-Cas12a genome editing of protein tyrosine phosphatases in human pluripotent stem cells and functional β-like cell generation

STAR Protocols
Summary: Gene editing of human pluripotent stem cells is a promising approach for developing targeted gene therapies for metabolic diseases. Here, we present a protocol for generating a CRISPR-Cas12a gene knockout of protein tyrosine phosphatases in ...
Javier Negueruela, Valerie Vandenbempt, Stephanie Talamantes, Francisco Ribeiro-Costa, Mariana Nunes, André Dias, Mayank Bansal, Esteban N. Gurzov   +7 more
doaj   +1 more source

Signal transduction pathways in the clinical approach: where are we going? [PDF]

, 2016
invited ...
LO VASCO, VINCENZA RITA
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Plasma Proteome Profiling to detect and avoid sample‐related biases in biomarker studies

EMBO Molecular Medicine, 2019
Plasma and serum are rich sources of information regarding an individual's health state, and protein tests inform medical decision making. Despite major investments, few new biomarkers have reached the clinic.
Philipp E Geyer, Eugenia Voytik, Peter V Treit, Sophia Doll, Alisa Kleinhempel, Lili Niu, Johannes B Müller, Marie‐Luise Buchholtz, Jakob M Bader, Daniel Teupser, Lesca M Holdt, Matthias Mann   +11 more
doaj   +1 more source

Protective role of all-trans retinoic acid (ATRA) against hypoxia-induced malignant potential of non-invasive breast tumor derived cells

BMC Cancer, 2018
Background The presence of hypoxic areas is common in all breast lesions but no data clearly correlate low oxygenation with the acquisition of malignant features by non-invasive cells, particularly by cells from ductal carcinoma in situ (DCIS), the most ...
Yasamin Al-Qassab, Silvia Grassilli, Federica Brugnoli, Federica Vezzali, Silvano Capitani, Valeria Bertagnolo   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Proteomic maps of breast cancer subtypes

Nature Communications, 2016
Breast cancers have been extensively studied at the genomic and transcriptomic levels in the hope of tailoring therapeutic regimens. Here the authors generate deep coverage proteomes from several clinical breast cancer samples, and use machine learning ...
Stefka Tyanova, Reidar Albrechtsen, Pauliina Kronqvist, Juergen Cox, Matthias Mann, Tamar Geiger   +5 more
doaj   +1 more source

The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2

BMC Cancer, 2018
Background Targeted therapy with trastuzumab has become a mainstay for HER2-positive breast cancer without a clear understanding of the mechanism of its action. While many mechanisms have been suggested for the action of trastuzumab, most of them are not
Hamid Maadi, Babak Nami, Junfeng Tong, Gina Li, Zhixiang Wang   +4 more
doaj   +1 more source

Requirement of JIP scaffold proteins for NMDA-mediated signal transduction [PDF]

, 2007
Norman J. Kennedy, Gilles Martin, Anka G Ehrhardt, Julie Cavanagh-Kyros, Chia-Yi Kuan, Pasko Rakić, Richard A. Flavell, Steven N. Treistman, Roger J. Davis   +8 more
openalex   +1 more source