Results 121 to 130 of about 1,096,363 (351)

Full coherent frequency conversion between two microwave propagating modes

, 2012
We demonstrate full frequency conversion in the microwave domain using a Josephson three-wave mixing device pumped at the difference between the frequencies of its fundamental eigenmodes.
Abdo, Baleegh, Bergeal, Nicolas, Devoret, Michel H., Frunzio, Luigi, Hatridge, Michael, Schackert, Flavius, Sliwa, Katrina, Stone, A. Douglas   +7 more
core   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

B lymphocyte activation. Transmembrane signal transduction by membrane immunoglobulin in isolated cell membranes. [PDF]

, 1987
L K Harris, John C. Cambier
openalex   +1 more source

Astabiotics: Antimicrobial Signal Transduction Activators [PDF]

, 2013
poster abstractThe increasing prevalence of multi-drug resistant Gram-negative bacteria is a major public health concern. All available antibiotics are inhibitors of targets essential for virulence or growth.
Chen, L., Fortney, K. R., Krieger, A., Mobley, H. L. T., Pollok, Karen E., Smith, S. N., Spinola, S. M., Wolfe, A. J., Zhang, Z.-Y., Zhou, D.   +9 more
core  

Non-equilibrium phase transitions in biomolecular signal transduction

, 2011
We study a mechanism for reliable switching in biomolecular signal-transduction cascades. Steady bistable states are created by system-size cooperative effects in populations of proteins, in spite of the fact that the phosphorylation-state transitions of
A. J. Ninfa, D. Kültz, David Krakauer, Eric Smith, H. Goldstein, J. Gluckheimer, J. von Neumann, L. V. Keldysh, S. Coleman, S. Gaudet, S. Weinberg, Supriya Krishnamurthy, W. Bialek, Walter Fontana   +13 more
core   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

G protein linked signal transduction pathways in development: Dictyostelium as an experimental system [PDF]

, 1989
Richard Firtel, Peter J.M. Van Haastert, Alan R. Kimmel, Peter N. Devreotes   +3 more
openalex   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Ia-mediated signal transduction leads to proliferation of primed B lymphocytes. [PDF]

, 1989
John C. Cambier, Kathrin Lehmann
openalex   +1 more source