Results 161 to 170 of about 1,137,727 (346)

Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells

Advanced Functional Materials, EarlyView.
CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham, Jose Gabriel Castro, Lisette C. Werba, Joseph Amitrano, Luke Fardone, Kevin P. Francis, Anand Ramamurthi, Michael J. Layden, Helen O. McCarthy, Tomas Gonzalez‐Fernandez   +9 more
wiley   +1 more source

The halobacterium salinarum taxis signal transduction network [PDF]

, 2008
Matthias Schlesner
openalex   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Insulin-like Growth Factor-I-Dependent Signal Transduction Pathways Leading to the Induction of Cell Growth and Differentiation of Human Neuroblastoma Cell Line SH-SY5Y. The Roles of MAP Kinase Pathway and PI 3-Kinase Pathway.

, 2000
Shigekazu Kurihara, Fumihiko Hakuno, Shin‐Ichiro Takahashi   +2 more
openalex   +2 more sources

Signal transduction 2000 [PDF]

Nature Biotechnology, 1999
openaire   +2 more sources

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source

Cell proliferation and glucose transport : the intracellular signal transduction pathways that mediate the early phase of growth factor-stimulated glucose transport [PDF]

, 1994
Nicola W. Merrall
openalex  

Polycyclic aromatic hydrocarbons induce migration in human hepatocellular carcinoma cells (HepG2) through reactive oxygen species‐mediated p38 MAPK signal transduction

, 2011
Mi‐Kyung Song, Youn‐Jung Kim, Mee Song, Han‐Seam Choi, Yong‐Keun Park, Jae‐Chun Ryu   +5 more
openalex   +2 more sources

Additively Manufactured Diamond for Energy Scavenging and Wireless Power Transfer in Implantable Devices

Advanced Functional Materials, EarlyView.
Additive manufacturing is expanding beyond mechanical prosthetics into microelectronic implants. This work presents a diamond‐titanium hybrid that enables wireless power transfer, localized heating, and flow sensing. The use of additive manufacturing combined with the biocompatibility of the diamond‐titanium hybrid material paves the way toward new ...
Joshua Zarins, Daniel De Maria, Alan Jones, Deepak Sharma, Amir Ebrahimi, Zhangyu Xu, Omid Kavehei, Peter C. Sherrell, Kate Fox, Arman Ahnood   +9 more
wiley   +1 more source

Acid Sphingomyelinase-Ceramide Induced Vascular Injury Determines Colorectal Cancer Stem Cell Fate

Cellular Physiology and Biochemistry, 2022
Christy Li, Stefan Klingler, Sahra Bodo, Jin Cheng, Yan Pan, Mohammed Adileh, Maria Laura Martin, John Fuller, Regina Feldman, Adam Michel, Zhigang Zhang, Zvi Fuks, Richard Kolesnick   +12 more
doaj   +1 more source