Results 161 to 170 of about 1,112,644 (355)

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.

, 1983
Hitoshi Kurose, Toshiaki Katada, Tomoko Amano, M Ui   +3 more
openalex   +1 more source

CD4 and CD8 are positive regulators of T cell receptor signal transduction in early T cell differentiation. [PDF]

, 1991
Lisa K. Gilliland, H S Teh, Fatih M. Uckun, Nancy Norris, Soo-Jeet Teh, Gary L. Schieven, J A Ledbetter   +6 more
openalex   +1 more source

Ultrasound compared to Computed Tomography in identifying thoracic aortic aneurysms in patients with Giant Cell Arteritis

Arthritis Care &Research, Accepted Article.
Objectives The objectives of this study were to evaluate the correlation and agreement between ultrasound and computed tomography (CT) in measuring ascending aorta diameter in patients with giant cell arteritis (GCA) and to investigate the development of new ascending aortic aneurysms in patients with newly diagnosed GCA. Methods To achieve the primary
Anne C Bull Haaversen, Lene K Brekke, Tanaz A Kermani, Øyvind Molberg, Andreas P Diamantopoulos   +4 more
wiley   +1 more source

Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4 [PDF]

, 1993
Yasuto Tanabe, Akihiro Nomura, Masayuki Masu, Ryuichi Shigemoto, Noboru Mizuno, Shigetada Nakanishi   +5 more
openalex   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway. [PDF]

, 1994
Michael T. Anderson, Frank J. T. Staal, Carlos Gitler, L A Herzenberg, L A Herzenberg   +4 more
openalex   +1 more source

Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell‐Based Model

Advanced Biology, EarlyView.
This study develops a tissue‐engineered model of the atherosclerotic cap using human mesenchymal stromal cells (MSCs). After 2 weeks of culture to produce a collagenous matrix, a mineralizing medium induces microcalcifications over 4 weeks. These constructs, imaged with second harmonic generation microscopy, lead to reduced ultimate stress at rupture ...
Imke L. Jansen, Deniz Şahin, Frank J.H. Gijsen, Eric Farrell, Kim van der Heiden   +4 more
wiley   +1 more source

Acid Sphingomyelinase-Ceramide Induced Vascular Injury Determines Colorectal Cancer Stem Cell Fate

Cellular Physiology and Biochemistry, 2022
Christy Li, Stefan Klingler, Sahra Bodo, Jin Cheng, Yan Pan, Mohammed Adileh, Maria Laura Martin, John Fuller, Regina Feldman, Adam Michel, Zhigang Zhang, Zvi Fuks, Richard Kolesnick   +12 more
doaj   +1 more source

Plasma membrane inositol 1,4,5-Trisphosphate-Activated channels mediate signal transduction in lobster olfactory receptor neurons [PDF]

, 1992
Debra Ann Fadool, B. W. Ache
openalex   +1 more source