Results 281 to 290 of about 795,179 (316)
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Signal transduction in erythropoiesis
The FASEB Journal, 1991The polypeptide hormone erythropoietin (Ep) is a growth factor whose actions on the erythroid progenitor cell induce proliferation and differentiation. The signal transduction system activated by Ep to mediate these cellular processes remains largely uncharacterized despite many years of research devoted to its elucidation.
M, Mason-Garcia, B S, Beckman
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International Journal of Cancer, 1989
Experiments using the physical loading of purified recombinant p21 ras proteins into quiescent normal cells to analyze how the proteins stimulate DNA synthesis and morphological transformation are reviewed. The results indicate that oncogenic p21ras proteins rapidly activate a protein-kinase-C-dependent pathway and a protein-kinase-C-independent ...
C J, Marshall +5 more
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Experiments using the physical loading of purified recombinant p21 ras proteins into quiescent normal cells to analyze how the proteins stimulate DNA synthesis and morphological transformation are reviewed. The results indicate that oncogenic p21ras proteins rapidly activate a protein-kinase-C-dependent pathway and a protein-kinase-C-independent ...
C J, Marshall +5 more
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Complexity in signal transduction
Annals of the New York Academy of Sciences, 2010This review is focused on complexity in cell signaling. Signaling experiments have demonstrated that many different stimuli activate the same signaling pathways yet result in different outcomes. Differences in the cellular machinery between cells explain response variation between cell types, but for a single cell type an appealing explanation is still
Jameel, Iqbal, Li, Sun, Mone, Zaidi
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Signal transduction in the parathyroid
Current Opinion in Nephrology and Hypertension, 2002To review recent developments regarding the mechanisms underlying the regulation of various aspects of parathyroid function.New studies published during the past year focused on calcium sensing via the calcium-sensing receptor, signal transduction within parathyroid cells, regulation of parathyroid hormone secretion, and the role of caveolae in calcium-
Olga, Kifor +2 more
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The ‘Gab’ in signal transduction
Trends in Cell Biology, 2003Tyrosine phosphorylation plays an important role in controlling cellular growth, differentiation and function. Abnormal regulation of tyrosine phosphorylation can result in human diseases such as cancer. A major challenge of signal transduction research is to determine how the initial activation of protein-tyrosine kinases (PTKs) by extracellular ...
Haihua, Gu, Benjamin G, Neel
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Integrins and Signal Transduction
2010Integrin signaling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellular signaling pathways triggered by integrins are directed to two major functions: organization of the actin cytoskeleton and regulation of cell behaviour ...
Sara, Cabodi +10 more
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Cytokines and signal transduction
The Clinical Investigator, 1994Cytokines are signaling molecules that coordinate cellular interactions in immune and hematopoietic systems. During the past 5 years many cytokines and their receptors have been identified and cloned. With a few exceptions, cytokine receptors do not contain any known signaling domains and therefore, in order to trigger a specific cellular response, new
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