Results 31 to 40 of about 1,214,945 (371)

Multi-omics analysis revealed the role of CCT2 in the induction of autophagy in Alzheimer’s disease

open access: yesFrontiers in Genetics, 2023
Chaperonin containing TCP1 subunit 2 (CCT2) is essential in various neurodegenerative diseases, albeit its role in the pathogenesis of Alzheimer’s disease (AD) remains elusive. This study aimed to evaluate the role of CCT2 in Alzheimer’s disease.
Xueting Ma   +6 more
doaj   +1 more source

Harnessing Brillouin Interaction in Rare-earth Aluminosilicate Glass Microwires for Optoelectromechanic Quantum Transduction [PDF]

open access: yesPhys. Lett. A 475, 128829 (2023), 2022
Quantum transduction, the process of converting quantum signals from one form of energy to another is a key step in harnessing different physical platforms and the associated qubits for quantum information processing. Optoelectromechanics has been one of the effective approaches to undertake transduction from optical-to-microwave signals, among others ...
arxiv   +1 more source

Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma

open access: yesMolecular Systems Biology, 2012
We report a proteomic analysis of microdissected material from formalin‐fixed and paraffin‐embedded colorectal cancer, quantifying >7500 proteins between patient matched normal mucosa, primary carcinoma, and nodal metastases.
Jacek R Wiśniewski   +5 more
doaj   +1 more source

Parametric Amplification of an Optomechanical Quantum Interconnect [PDF]

open access: yes, 2022
Connecting superconducting qubits to optical fiber necessitates the conversion of microwave photons to optical photons. Modern experimental demonstrations exhibit strong coupling between a microwave resonator and an optical cavity mediated through phononic modes in a mechanical oscillator.
arxiv   +1 more source

SILAC-based quantitative proteomics using mass spectrometry quantifies endoplasmic reticulum stress in whole HeLa cells

open access: yesDisease Models & Mechanisms, 2019
The unfolded protein response (UPR) involves extensive proteome remodeling in many cellular compartments. To date, a comprehensive analysis of the UPR has not been possible because of technological limitations.
Daniel N. Itzhak   +5 more
doaj   +1 more source

Identification of Scopoletin and Chlorogenic Acid as Potential Active Components in Sunflower Calathide Enzymatically Hydrolyzed Extract towards Hyperuricemia

open access: yesApplied Sciences, 2021
It is known that sunflower (Helianthus annuus L.) calathide enzymatically hydrolyzed extract (SCHE) contributes to the regulation of serum uric acid (UA); however, evidence regarding its bioactive components and mechanism are lacking.
Huining Dai   +3 more
doaj   +1 more source

Signal transduction gRABs attention [PDF]

open access: yes, 2006
Rab proteins are small GTPases involved in the regulation of vesicular membrane traffic. Research done in the past years has demonstrated that some of these proteins are under the control of signal transduction pathways.
Bucci, Cecilia, Chiariello, Mario
core   +1 more source

Response to exercise‐induced blood pressure elevation is blunted in wrist‐cuff automated oscillometric measurement in healthy young college students

open access: yesPhysiological Reports, 2020
Background A wrist‐cuff automated oscillometric device is portable and useful for self‐monitoring of blood pressure (BP) at home and outdoors when an upper arm device is not available.
Tatsuya Sato   +6 more
doaj   +1 more source

Conidiation in Neurospora crassa: vegetative reproduction by a model fungus [PDF]

open access: yes, 2019
Asexual development, conidiation, in the filamentous fungus Neurospora crassa is a simple developmental process that starts with the growth of aerial hyphae.
Corrochano Peláez, Luis María   +1 more
core   +1 more source

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

open access: yesNature Communications, 2018
How tumor cells control metastatic niche formation is not fully understood. Here, the authors show in a lung metastatic niche, high-metastatic hepatocellular carcinoma cells secrete exosomal miR-1247-3p that leads to activation of β1-integrin-NF ...
Tian Fang   +15 more
doaj   +1 more source

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