Results 31 to 40 of about 1,119,972 (297)

Global, quantitative and dynamic mapping of protein subcellular localization

eLife, 2016
Subcellular localization critically influences protein function, and cells control protein localization to regulate biological processes. We have developed and applied Dynamic Organellar Maps, a proteomic method that allows global mapping of protein ...
Daniel N Itzhak, Stefka Tyanova, Jürgen Cox, Georg HH Borner   +3 more
doaj   +1 more source

Fold-Hopf Bursting in a Model for Calcium Signal Transduction

, 2002
We study a recent model for calcium signal transduction. This model displays spiking, bursting and chaotic oscillations in accordance with experimental results. We calculate bifurcation diagrams and study the bursting behaviour in detail.
Brusch, Lutz, Bär, Markus, Kummer, Ursula, Lorenz, Wolfram, Or-Guil, Michal   +4 more
core   +1 more source

Response to exercise‐induced blood pressure elevation is blunted in wrist‐cuff automated oscillometric measurement in healthy young college students

Physiological Reports, 2020
Background A wrist‐cuff automated oscillometric device is portable and useful for self‐monitoring of blood pressure (BP) at home and outdoors when an upper arm device is not available.
Tatsuya Sato, Nobutoshi Ichise, Yoshinori Terashima, Aoi Kato, Hiroya Yamazaki, Shunsuke Jimbo, Noritsugu Tohse   +6 more
doaj   +1 more source

Identification of Scopoletin and Chlorogenic Acid as Potential Active Components in Sunflower Calathide Enzymatically Hydrolyzed Extract towards Hyperuricemia

Applied Sciences, 2021
It is known that sunflower (Helianthus annuus L.) calathide enzymatically hydrolyzed extract (SCHE) contributes to the regulation of serum uric acid (UA); however, evidence regarding its bioactive components and mechanism are lacking.
Huining Dai, Shuai Lv, Xueqi Fu, Wannan Li   +3 more
doaj   +1 more source

Optimal length and signal amplification in weakly activated signal transduction cascades

, 2003
Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system, provide natural measures for the propagation of the input signal down the cascade and for the ...
Chaves, Madalena, Dinerstein, Robert J., Sontag, Eduardo D.   +2 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Genome editing of TXNIP in human pluripotent stem cells for the generation of hepatocyte-like cells and insulin-producing islet-like aggregates

Stem Cell Research & Therapy
Background Thioredoxin-interacting protein (TXNIP) plays a role in regulating endoplasmic reticulum (ER) and oxidative stress, which disrupt glucose homeostasis in diabetes. However, the impact of TXNIP deficiency on the differentiation and functionality
Leonardo Traini, Javier Negueruela, Bernat Elvira, Wadsen St-Pierre-Wijckmans, Valerie Vandenbempt, Carlos E. Buss, Ao Li, Israel Pérez-Chávez, Francisco Ribeiro-Costa, Mariana Nunes, Joris Messens, Daria Ezeriņa, David C. Hay, Mayank Bansal, Esteban N. Gurzov   +14 more
doaj   +1 more source

Serotonin-promoted elevation of ROS levels may lead to cardiac pathologies in diabetic rat [PDF]

Archives of Biological Sciences, 2015
Patients with diabetes mellitus (DM) develop tendencies toward heart disease. Hyperglycemia induces the release of serotonin from enterochromaffin cells (EC).
Ali Tahir, Shaheen Farhat, Mahmud Madiha, Waheed Hina, Ishtiaq Muhammad, Javed Qamar, Murtaza Iram   +6 more
doaj   +1 more source

Capacity of a Simple Intercellular Signal Transduction Channel

, 2013
We model the ligand-receptor molecular communication channel with a discrete-time Markov model, and show how to obtain the capacity of this channel. We show that the capacity-achieving input distribution is iid; further, unusually for a channel with ...
Eckford, Andrew W., Thomas, Peter J.
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source