Results 31 to 40 of about 1,112,644 (355)

Global, quantitative and dynamic mapping of protein subcellular localization

eLife, 2016
Subcellular localization critically influences protein function, and cells control protein localization to regulate biological processes. We have developed and applied Dynamic Organellar Maps, a proteomic method that allows global mapping of protein ...
Daniel N Itzhak, Stefka Tyanova, Jürgen Cox, Georg HH Borner   +3 more
doaj   +1 more source

Identification of Scopoletin and Chlorogenic Acid as Potential Active Components in Sunflower Calathide Enzymatically Hydrolyzed Extract towards Hyperuricemia

Applied Sciences, 2021
It is known that sunflower (Helianthus annuus L.) calathide enzymatically hydrolyzed extract (SCHE) contributes to the regulation of serum uric acid (UA); however, evidence regarding its bioactive components and mechanism are lacking.
Huining Dai, Shuai Lv, Xueqi Fu, Wannan Li   +3 more
doaj   +1 more source

Finite-State Channel Models for Signal Transduction in Neural Systems

, 2016
Information theory provides powerful tools for understanding communication systems. This analysis can be applied to intercellular signal transduction, which is a means of chemical communication among cells and microbes.
Eckford, Andrew W., Loparo, Kenneth A., Thomas, Peter J.   +2 more
core   +1 more source

Mitochondrial signal transduction

Cell Metabolism, 2022
The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue that mitochondria are the processor of the cell, and together with the nucleus and other organelles they constitute the ...
Picard, Martin, Shirihai, Orian S.
openaire   +2 more sources

Fold-Hopf Bursting in a Model for Calcium Signal Transduction

, 2002
We study a recent model for calcium signal transduction. This model displays spiking, bursting and chaotic oscillations in accordance with experimental results. We calculate bifurcation diagrams and study the bursting behaviour in detail.
Brusch, Lutz, Bär, Markus, Kummer, Ursula, Lorenz, Wolfram, Or-Guil, Michal   +4 more
core   +1 more source

Serotonin-promoted elevation of ROS levels may lead to cardiac pathologies in diabetic rat [PDF]

Archives of Biological Sciences, 2015
Patients with diabetes mellitus (DM) develop tendencies toward heart disease. Hyperglycemia induces the release of serotonin from enterochromaffin cells (EC).
Ali Tahir, Shaheen Farhat, Mahmud Madiha, Waheed Hina, Ishtiaq Muhammad, Javed Qamar, Murtaza Iram   +6 more
doaj   +1 more source

Optimal length and signal amplification in weakly activated signal transduction cascades

, 2003
Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system, provide natural measures for the propagation of the input signal down the cascade and for the ...
Chaves, Madalena, Dinerstein, Robert J., Sontag, Eduardo D.   +2 more
core   +2 more sources

A variational approach to the stochastic aspects of cellular signal transduction [PDF]

, 2006
Cellular signaling networks have evolved to cope with intrinsic fluctuations, coming from the small numbers of constituents, and the environmental noise.
Alberts B., Elowitz M. B., Gardiner C. W., Garegin A. Papoian, Golub G., Gomperts B. D., Meng T. C., Peter G. Wolynes, Press W. H., Reichl L. E., Seger R., Shvartsman S. Y., van Kampen N. G., Yueheng Lan, Zel’dovich Y. B.   +14 more
core   +3 more sources

Oxygen Signal Transduction [PDF]

IUBMB Life, 2001
AbstractAlthough manifestations of O 2 adaptation have long been examined, only now are biochemical mechanisms of O 2 regulation beginning to be understood. This article comments on the current state of knowledge about proteins that function as direct sensors of molecular oxygen and makes predictions about as yet undiscovered sensors.
openaire   +3 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source