Results 41 to 50 of about 1,137,727 (346)

Finite-State Channel Models for Signal Transduction in Neural Systems

, 2016
Information theory provides powerful tools for understanding communication systems. This analysis can be applied to intercellular signal transduction, which is a means of chemical communication among cells and microbes.
Eckford, Andrew W., Loparo, Kenneth A., Thomas, Peter J.   +2 more
core   +1 more source

Optimal length and signal amplification in weakly activated signal transduction cascades

, 2003
Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system, provide natural measures for the propagation of the input signal down the cascade and for the ...
Chaves, Madalena, Dinerstein, Robert J., Sontag, Eduardo D.   +2 more
core   +2 more sources

Watching the hands of the Arabidopsis biological clock [PDF]

, 2001
Oligonucleotide and cDNA microarrays have been used to analyse the mRNA levels of 8,000 genes in Arabidopsis thaliana throughout the day/night cycle. Genes involved in signal transduction and in various metabolic pathways were found to be coordinately ...
Davis, Seth J., Millar, A. J. (Andrew J.)   +1 more
core   +2 more sources

Identification of Scopoletin and Chlorogenic Acid as Potential Active Components in Sunflower Calathide Enzymatically Hydrolyzed Extract towards Hyperuricemia

Applied Sciences, 2021
It is known that sunflower (Helianthus annuus L.) calathide enzymatically hydrolyzed extract (SCHE) contributes to the regulation of serum uric acid (UA); however, evidence regarding its bioactive components and mechanism are lacking.
Huining Dai, Shuai Lv, Xueqi Fu, Wannan Li   +3 more
doaj   +1 more source

Fold-Hopf Bursting in a Model for Calcium Signal Transduction

, 2002
We study a recent model for calcium signal transduction. This model displays spiking, bursting and chaotic oscillations in accordance with experimental results. We calculate bifurcation diagrams and study the bursting behaviour in detail.
Brusch, Lutz, Bär, Markus, Kummer, Ursula, Lorenz, Wolfram, Or-Guil, Michal   +4 more
core   +1 more source

Thermodynamic and Kinetic Analysis of Sensitivity Amplification in Biological Signal Transduction [PDF]

, 2002
Based on a thermodynamic analysis of the kinetic model for the protein phosphorylation-dephosphorylation cycle, we study the ATP (or GTP) energy utilization of this ubiquitous biological signal transduction process.
Bourne, Ferrell, Goldbeter, Goldbeter, Gresser, Hartwell, Hill, Hill, Hopfield, Hopfield, Huang, Koshland, Koshland, Krebs, Kushmerick, Li, McKeithan, Poland, Qian, Qian, Shacter, Stadtman, Stryer, Wyman   +23 more
core   +5 more sources

Serotonin-promoted elevation of ROS levels may lead to cardiac pathologies in diabetic rat [PDF]

Archives of Biological Sciences, 2015
Patients with diabetes mellitus (DM) develop tendencies toward heart disease. Hyperglycemia induces the release of serotonin from enterochromaffin cells (EC).
Ali Tahir, Shaheen Farhat, Mahmud Madiha, Waheed Hina, Ishtiaq Muhammad, Javed Qamar, Murtaza Iram   +6 more
doaj   +1 more source

A variational approach to the stochastic aspects of cellular signal transduction [PDF]

, 2006
Cellular signaling networks have evolved to cope with intrinsic fluctuations, coming from the small numbers of constituents, and the environmental noise.
Alberts B., Elowitz M. B., Gardiner C. W., Garegin A. Papoian, Golub G., Gomperts B. D., Meng T. C., Peter G. Wolynes, Press W. H., Reichl L. E., Seger R., Shvartsman S. Y., van Kampen N. G., Yueheng Lan, Zel’dovich Y. B.   +14 more
core   +3 more sources

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

Genome editing of TXNIP in human pluripotent stem cells for the generation of hepatocyte-like cells and insulin-producing islet-like aggregates

Stem Cell Research & Therapy
Background Thioredoxin-interacting protein (TXNIP) plays a role in regulating endoplasmic reticulum (ER) and oxidative stress, which disrupt glucose homeostasis in diabetes. However, the impact of TXNIP deficiency on the differentiation and functionality
Leonardo Traini, Javier Negueruela, Bernat Elvira, Wadsen St-Pierre-Wijckmans, Valerie Vandenbempt, Carlos E. Buss, Ao Li, Israel Pérez-Chávez, Francisco Ribeiro-Costa, Mariana Nunes, Joris Messens, Daria Ezeriņa, David C. Hay, Mayank Bansal, Esteban N. Gurzov   +14 more
doaj   +1 more source