Results 41 to 50 of about 1,112,644 (355)

Impact of sorbic acid on germinant receptor-dependent and -independent germination pathways in Bacillus cereus [PDF]

, 2011
Amino acid- and inosine-induced germination of Bacillus cereus ATCC 14579 spores was reversibly inhibited in the presence of 3 mM undissociated sorbic acid. Exposure to high hydrostatic pressure, Ca-dipicolinic acid (DPA), and bryostatin, an activator of
Abee, T., Melis, C.C.J., van, Nierop Groot, M.N.   +2 more
core   +2 more sources

Genome editing of TXNIP in human pluripotent stem cells for the generation of hepatocyte-like cells and insulin-producing islet-like aggregates

Stem Cell Research & Therapy
Background Thioredoxin-interacting protein (TXNIP) plays a role in regulating endoplasmic reticulum (ER) and oxidative stress, which disrupt glucose homeostasis in diabetes. However, the impact of TXNIP deficiency on the differentiation and functionality
Leonardo Traini, Javier Negueruela, Bernat Elvira, Wadsen St-Pierre-Wijckmans, Valerie Vandenbempt, Carlos E. Buss, Ao Li, Israel Pérez-Chávez, Francisco Ribeiro-Costa, Mariana Nunes, Joris Messens, Daria Ezeriņa, David C. Hay, Mayank Bansal, Esteban N. Gurzov   +14 more
doaj   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Capacity of a Simple Intercellular Signal Transduction Channel

, 2013
We model the ligand-receptor molecular communication channel with a discrete-time Markov model, and show how to obtain the capacity of this channel. We show that the capacity-achieving input distribution is iid; further, unusually for a channel with ...
Eckford, Andrew W., Thomas, Peter J.
core   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling

Cell Reports, 2014
Regulatory protein phosphorylation controls normal and pathophysiological signaling in eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the extent, localization, and site-specific stoichiometry of this posttranslational ...
Kirti Sharma, Rochelle C.J. D’Souza, Stefka Tyanova, Christoph Schaab, Jacek R. Wiśniewski, Jürgen Cox, Matthias Mann   +6 more
doaj   +1 more source

Origin of life: β‐sheet amyloid conformers as the primordial functional polymers on the early Earth and their role in the emergence of complex dynamic networks

FEBS Letters, EarlyView.
The amyloid world hypothesis of the origin‐of‐life posits that the first functional polymers on the early Earth were structurally stable cross‐β‐sheet‐based peptide amyloids capable of Darwinian‐like evolution. Peptide amyloids display self‐replication and information transfer, as well as catalytic, adaptive, and evolutive properties.
Carl Peter J. Maury
wiley   +1 more source

Thermodynamic and Kinetic Analysis of Sensitivity Amplification in Biological Signal Transduction [PDF]

, 2002
Based on a thermodynamic analysis of the kinetic model for the protein phosphorylation-dephosphorylation cycle, we study the ATP (or GTP) energy utilization of this ubiquitous biological signal transduction process.
Bourne, Ferrell, Goldbeter, Goldbeter, Gresser, Hartwell, Hill, Hill, Hopfield, Hopfield, Huang, Koshland, Koshland, Krebs, Kushmerick, Li, McKeithan, Poland, Qian, Qian, Shacter, Stadtman, Stryer, Wyman   +23 more
core   +5 more sources

Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function

Molecules, 2018
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an intracellular cysteine protease (paracaspase) that plays an integral role in innate and adaptive immunity.
Laura Meloni, Lynn Verstrepen, Marja Kreike, Jens Staal, Yasmine Driege, Inna S. Afonina, Rudi Beyaert   +6 more
doaj   +1 more source

Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells

Nature Communications, 2021
Long term haematopoitic stem cells (LT-HSCs) are in a quiescent state during homeostasis, which is critical for their maintenance. Here, the authors show that Gal-3 expression in LT-HSCs is induced in response to Tie2 and Mpl and is both necessary and ...
Weizhen Jia, Lingyu Kong, Hiroyasu Kidoya, Hisamichi Naito, Fumitaka Muramatsu, Yumiko Hayashi, Han-Yun Hsieh, Daishi Yamakawa, Daniel K. Hsu, Fu-Tong Liu, Nobuyuki Takakura   +10 more
doaj   +1 more source