Results 41 to 50 of about 1,214,945 (371)
Global, quantitative and dynamic mapping of protein subcellular localization
eLife, 2016 Subcellular localization critically influences protein function, and cells control protein localization to regulate biological processes. We have developed and applied Dynamic Organellar Maps, a proteomic method that allows global mapping of protein ...
Daniel N Itzhak +3 more
doaj +1 more source
Self-organization of signal transduction
, 2013 We propose a model of parameter learning for signal transduction, where the objective function is defined by signal transmission efficiency. We apply this to learn kinetic rates as a form of evolutionary learning, and look for parameters which satisfy ...
Scheler, Gabriele
core +2 more sources
CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition. [PDF]
, 2019 Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a genetically heterogeneous subtype of B-cell ALL characterized by chromosomal rearrangements and mutations that result in aberrant cytokine receptor and kinase signaling.
Delgado-Martin, Cristina +5 more
core +2 more sources
Serotonin-promoted elevation of ROS levels may lead to cardiac pathologies in diabetic rat [PDF]
Archives of Biological Sciences, 2015 Patients with diabetes mellitus (DM) develop tendencies toward heart disease. Hyperglycemia induces the release of serotonin from enterochromaffin cells (EC).
Ali Tahir +6 more
doaj +1 more source
Optimal length and signal amplification in weakly activated signal transduction cascades
, 2003 Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system, provide natural measures for the propagation of the input signal down the cascade and for the ...
Chaves, Madalena +2 more
core +2 more sources
Mitochondrial signal transduction
Cell Metabolism, 2022 The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue that mitochondria are the processor of the cell, and together with the nucleus and other organelles they constitute the ...
Picard, Martin, Shirihai, Orian S.
openaire +2 more sources
Dynamic Studies of Scaffold-dependent Mating Pathway in Yeast [PDF]
, 2006 The mating pathway in \emph{Saccharomyces cerevisiae} is one of the best understood signal transduction pathways in eukaryotes. It transmits the mating signal from plasma membrane into the nucleus through the G-protein coupled receptor and the mitogen ...
Ouyang, Qi +4 more
core +3 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells
Nature Communications, 2021 Long term haematopoitic stem cells (LT-HSCs) are in a quiescent state during homeostasis, which is critical for their maintenance. Here, the authors show that Gal-3 expression in LT-HSCs is induced in response to Tie2 and Mpl and is both necessary and ...
Weizhen Jia +10 more
doaj +1 more source
Fold-Hopf Bursting in a Model for Calcium Signal Transduction
, 2002 We study a recent model for calcium signal transduction. This model displays spiking, bursting and chaotic oscillations in accordance with experimental results. We calculate bifurcation diagrams and study the bursting behaviour in detail.
Brusch, Lutz +4 more
core +1 more source