Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.
Physiological Reviews, 2018 The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology and pathophysiology. However, many of the signaling mechanisms have been unclear.
Steven J Forrester +7 more
semanticscholar +1 more source
Self-organization of signal transduction
, 2013 We propose a model of parameter learning for signal transduction, where the objective function is defined by signal transmission efficiency. We apply this to learn kinetic rates as a form of evolutionary learning, and look for parameters which satisfy ...
Scheler, Gabriele
core +2 more sources
Finite-State Channel Models for Signal Transduction in Neural Systems
, 2016 Information theory provides powerful tools for understanding communication systems. This analysis can be applied to intercellular signal transduction, which is a means of chemical communication among cells and microbes.
Eckford, Andrew W. +2 more
core +1 more source
Conidiation in Neurospora crassa: vegetative reproduction by a model fungus [PDF]
, 2019 Asexual development, conidiation, in the filamentous fungus Neurospora crassa is a simple developmental process that starts with the growth of aerial hyphae.
Corrochano Peláez, Luis María +1 more
core +1 more source
Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells
Nature Communications, 2021 Long term haematopoitic stem cells (LT-HSCs) are in a quiescent state during homeostasis, which is critical for their maintenance. Here, the authors show that Gal-3 expression in LT-HSCs is induced in response to Tie2 and Mpl and is both necessary and ...
Weizhen Jia +10 more
doaj +1 more source
Optimal length and signal amplification in weakly activated signal transduction cascades
, 2003 Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system, provide natural measures for the propagation of the input signal down the cascade and for the ...
Chaves, Madalena +2 more
core +2 more sources
CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition. [PDF]
, 2019 Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a genetically heterogeneous subtype of B-cell ALL characterized by chromosomal rearrangements and mutations that result in aberrant cytokine receptor and kinase signaling.
Delgado-Martin, Cristina +5 more
core +2 more sources
Psychological bulletin, 2014 Major life stressors, especially those involving interpersonal stress and social rejection, are among the strongest proximal risk factors for depression.
George M. Slavich, M. Irwin
semanticscholar +1 more source
Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function
Molecules, 2018 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an intracellular cysteine protease (paracaspase) that plays an integral role in innate and adaptive immunity.
Laura Meloni +6 more
doaj +1 more source
Attachment of HeLa cells during early G1 phase [PDF]
, 2011 Both growth factor directed and integrin dependent signal transduction were shown to take place directly after completion of mitosis. The local activation of these signal transduction cascades was investigated in early G1 cells.
B Payrastre +37 more
core +2 more sources