Results 61 to 70 of about 1,096,363 (351)

Role of cyclic AMP in the control of cell-specific gene expression [PDF]

, 1993
Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael, Nitsch, Doris, Schmid, Wolfgang, Schütz, Günther   +3 more
core   +1 more source

Signal Transduction in Cancer [PDF]

Cold Spring Harbor Perspectives in Medicine, 2015
Cancer is driven by genetic and epigenetic alterations that allow cells to overproliferate and escape mechanisms that normally control their survival and migration. Many of these alterations map to signaling pathways that control cell growth and division, cell death, cell fate, and cell motility, and can be placed in the context of distortions of wider
Joan S. Brugge, Richard Sever
openaire   +2 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

APJ regulates the balance between self-renewal and differentiation of vascular endothelial stem cells

Inflammation and Regeneration
Background CD157 marks a population of tissue-resident vascular endothelial stem cells (VESCs) in mice known for their critical role in homeostatic endothelial cell (EC) turnover and the rapid response to vascular damage in the liver by regeneration ...
Man Wang, Fitriana Nur Rahmawati, Wenting Li, Zeynep Bal, Faya Nuralda Sitompul, Fumitaka Muramatsu, Weizhen Jia, Nobuyuki Takakura   +7 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Role of functionality in two-component signal transduction: A stochastic study

, 2014
We present a stochastic formalism for signal transduction processes in bacterial two-component system. Using elementary mass action kinetics, the proposed model takes care of signal transduction in terms of phosphotransfer mechanism between the cognate ...
Bandyopadhyay, Arnab, Banik, Suman K, Chaudhury, Pinaki, Maity, Alok Kumar   +3 more
core   +1 more source

Atomic microwave-to-optical signal transduction via magnetic-field coupling in a resonant microwave cavity

, 2020
Atomic vapors offer many opportunities for manipulating electromagnetic signals across a broad range of the electromagnetic spectrum. Here, a microwave signal with an audio-frequency modulation encodes information in an optical signal by exploiting an ...
Davis, J. P., LeBlanc, L. J., Lee, T. S., Potts, C. A., Thiessen, M. J., Tretiakov, A.   +5 more
core   +1 more source

Insights into the behaviour of systems biology models from dynamic sensitivity and identifiability analysis: a case study of an NF-kB signaling pathway [PDF]

, 2006
Mathematical modelling offers a variety of useful techniques to help in understanding the intrinsic behaviour of complex signal transduction networks. From the system engineering point of view, the dynamics of metabolic and signal transduction models can
Broomhead, David S., Brown, Martin, Kell, Douglas B., Knowles, Joshua, Wang, Hong, Yue, Hong   +5 more
core   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Optimal Phosphorylation Step Number of Intracellular Signal Transduction Pathway [PDF]

, 2005
Eukaryotic cells use signal transduction network to respond in specific ways to external signals from their environment. Several signal transduction pathway are composed of multi-step chemical reactions.
Nakabayashi, J., Sasaki, A.
core