Results 81 to 90 of about 4,996,865 (347)

Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks

Journal of Clinical Medicine, 2016
Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing, and cancer development. It involves cooperation of signaling pathways, such as transformation growth factor-β (TGF-β), Sonic Hedgehog (SHH), and WNT pathways.
Jingyu Zhang, Xiao-Jun Tian, Jianhua Xing   +2 more
semanticscholar   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

An introduction to Biomodel engineering, illustrated for signal transduction pathways [PDF]

, 2009
BioModel Engineering is the science of designing, constructing and analyzing computational models of biological systems. It is inspired by concepts from software engineering and computing science.
Breitling, R, Donaldson, R, Gilbert, D, Heiner, M   +3 more
core   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Deep learning the collisional cross sections of the peptide universe from a million experimental values

Nature Communications, 2021
Proteomics has been advanced by algorithms that can predict different peptide features, but predicting peptide collisional cross sections (CCS) has remained challenging.
Florian Meier, Niklas D. Köhler, Andreas-David Brunner, Jean-Marc H. Wanka, Eugenia Voytik, Maximilian T. Strauss, Fabian J. Theis, Matthias Mann   +7 more
doaj   +1 more source

Modeling Evolution of Crosstalk in Noisy Signal Transduction Networks

, 2017
Signal transduction networks can form highly interconnected systems within cells due to network crosstalk, the sharing of input signals between multiple downstream responses.
Mukhopadhyay, Ranjan, Tareen, Ammar, Wingreen, Ned S.   +2 more
core   +1 more source

EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells [PDF]

, 2009
The EGF-related protein EFEMP1 (EGF-containing fibulin-like extracellular matrix protein 1) has been shown to promote tumor growth in human adenocarcinoma.
Blum, Helmut, Bruns, Christiane J., Camaj, Peter, De Toni, Enrico N., Faktorova, Dagmar, Ischenko, Ivan, Jauch, Karl-Walter, Krebs, Stefan, Seeliger, Hendrik   +8 more
core   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

The evolution of animal Argonautes: evidence for the absence of antiviral AGO Argonautes in vertebrates

Scientific Reports, 2017
In addition to mediating regulation of endogenous gene expression, RNA interference (RNAi) in plants and invertebrates plays a crucial role in defense against viruses via virus-specific siRNAs.
Niels Wynant, Dulce Santos, Jozef Vanden Broeck   +2 more
doaj   +1 more source

OSlgg: An Online Prognostic Biomarker Analysis Tool for Low-Grade Glioma

Frontiers in Oncology, 2020
Glioma is the most frequent primary brain tumor that causes high mortality and morbidity with poor prognosis. There are four grades of gliomas, I to IV, among which grade II and III are low-grade glioma (LGG).
Yang An, Qiang Wang, Lu Zhang, Fengjie Sun, Guosen Zhang, Huan Dong, Yingkun Li, Yanyu Peng, Haojie Li, Wan Zhu, Shaoping Ji, Yunlong Wang, Xiangqian Guo   +12 more
doaj   +1 more source